3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee

Abstract Microwave ablation has been widely accepted in treating bone tumor. However, its procedure is time-consuming and usually results in postoperative fractures. To solve this problem, we designed and fabricated titanium plates customized to the patients’ bone structures. The personalized titani...

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Autores principales:	Limin Ma, Ye Zhou, Ye Zhu, Zefeng Lin, Lingling Chen, Yu Zhang, Hong Xia, Chuanbin Mao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3846d9312ab8445792a1868043350397
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spelling	oai:doaj.org-article:3846d9312ab8445792a18680433503972021-12-02T16:06:38Z3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee10.1038/s41598-017-07243-32045-2322https://doaj.org/article/3846d9312ab8445792a18680433503972017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07243-3https://doaj.org/toc/2045-2322Abstract Microwave ablation has been widely accepted in treating bone tumor. However, its procedure is time-consuming and usually results in postoperative fractures. To solve this problem, we designed and fabricated titanium plates customized to the patients’ bone structures. The personalized titanium plates were then used for fixation after the removal of tumorous tissue. Specifically, 3D models of tumor-bearing bone segments were constructed by using computed tomography (CT) and magnetic resonance imaging (MRI). The 3D models were used to design the personalized titanium plates. The plate model was transferred into a numerical control machine for manufacturing the personalized titanium plates by 3D printing. The plates were then surgically implanted for reconstruction assistance following microwave-induced hyperthermia to remove the bone tumor. Implementation parameters and knee functions were then evaluated. No postoperative fractures, implant failures or loosening problems occurred; mean Musculoskeletal Tumor Society score was 27.17 from the latest follow-up. Mean maximum flexion of affected knees was 114.08°. The results of knee gait analysis were comparable with normal population data. Our work suggests that personalized titanium plates can significantly improve the clinical outcomes in the surgical removal of bone tumor. This study represents the first-time effort in using personalized titanium plates for such surgery.Limin MaYe ZhouYe ZhuZefeng LinLingling ChenYu ZhangHong XiaChuanbin MaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Limin Ma Ye Zhou Ye Zhu Zefeng Lin Lingling Chen Yu Zhang Hong Xia Chuanbin Mao 3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee
description	Abstract Microwave ablation has been widely accepted in treating bone tumor. However, its procedure is time-consuming and usually results in postoperative fractures. To solve this problem, we designed and fabricated titanium plates customized to the patients’ bone structures. The personalized titanium plates were then used for fixation after the removal of tumorous tissue. Specifically, 3D models of tumor-bearing bone segments were constructed by using computed tomography (CT) and magnetic resonance imaging (MRI). The 3D models were used to design the personalized titanium plates. The plate model was transferred into a numerical control machine for manufacturing the personalized titanium plates by 3D printing. The plates were then surgically implanted for reconstruction assistance following microwave-induced hyperthermia to remove the bone tumor. Implementation parameters and knee functions were then evaluated. No postoperative fractures, implant failures or loosening problems occurred; mean Musculoskeletal Tumor Society score was 27.17 from the latest follow-up. Mean maximum flexion of affected knees was 114.08°. The results of knee gait analysis were comparable with normal population data. Our work suggests that personalized titanium plates can significantly improve the clinical outcomes in the surgical removal of bone tumor. This study represents the first-time effort in using personalized titanium plates for such surgery.
format	article
author	Limin Ma Ye Zhou Ye Zhu Zefeng Lin Lingling Chen Yu Zhang Hong Xia Chuanbin Mao
author_facet	Limin Ma Ye Zhou Ye Zhu Zefeng Lin Lingling Chen Yu Zhang Hong Xia Chuanbin Mao
author_sort	Limin Ma
title	3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee
title_short	3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee
title_full	3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee
title_fullStr	3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee
title_full_unstemmed	3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee
title_sort	3d printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3846d9312ab8445792a1868043350397
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3D printed personalized titanium plates improve clinical outcome in microwave ablation of bone tumors around the knee

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