Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.

MAK-V/Hunk is a scantily characterized AMPK-like protein kinase. Recent findings identified MAK-V as a pro-survival and anti-apoptotic protein and revealed its role in embryonic development as well as in tumorigenesis and metastasis. However molecular mechanisms of MAK-V action and regulation of its...

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Autores principales:	Svetlana V Kalinichenko, Keiji Itoh, Elena V Korobko, Sergei Y Sokol, Vladimir L Buchman, Igor V Korobko
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/384c65e2d6b54befaad2724241647885
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spelling	oai:doaj.org-article:384c65e2d6b54befaad27242416478852021-11-18T07:14:48ZIdentification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.1932-620310.1371/journal.pone.0039505https://doaj.org/article/384c65e2d6b54befaad27242416478852012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22745772/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203MAK-V/Hunk is a scantily characterized AMPK-like protein kinase. Recent findings identified MAK-V as a pro-survival and anti-apoptotic protein and revealed its role in embryonic development as well as in tumorigenesis and metastasis. However molecular mechanisms of MAK-V action and regulation of its activity remain largely unknown. We identified Nedd4 as an interaction partner for MAK-V protein kinase. However, this HECT-type E3 ubiquitin ligase is not involved in the control of MAK-V degradation by the ubiquitin-proteasome system that regulates MAK-V abundance in cells. However, Nedd4 in an ubiquitin ligase-independent manner rescued developmental defects in Xenopus embryos induced by MAK-V overexpression, suggesting physiological relevance of interaction between MAK-V and Nedd4. This identifies Nedd4 as the first known regulator of MAK-V function.Svetlana V KalinichenkoKeiji ItohElena V KorobkoSergei Y SokolVladimir L BuchmanIgor V KorobkoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39505 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Svetlana V Kalinichenko Keiji Itoh Elena V Korobko Sergei Y Sokol Vladimir L Buchman Igor V Korobko Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.
description	MAK-V/Hunk is a scantily characterized AMPK-like protein kinase. Recent findings identified MAK-V as a pro-survival and anti-apoptotic protein and revealed its role in embryonic development as well as in tumorigenesis and metastasis. However molecular mechanisms of MAK-V action and regulation of its activity remain largely unknown. We identified Nedd4 as an interaction partner for MAK-V protein kinase. However, this HECT-type E3 ubiquitin ligase is not involved in the control of MAK-V degradation by the ubiquitin-proteasome system that regulates MAK-V abundance in cells. However, Nedd4 in an ubiquitin ligase-independent manner rescued developmental defects in Xenopus embryos induced by MAK-V overexpression, suggesting physiological relevance of interaction between MAK-V and Nedd4. This identifies Nedd4 as the first known regulator of MAK-V function.
format	article
author	Svetlana V Kalinichenko Keiji Itoh Elena V Korobko Sergei Y Sokol Vladimir L Buchman Igor V Korobko
author_facet	Svetlana V Kalinichenko Keiji Itoh Elena V Korobko Sergei Y Sokol Vladimir L Buchman Igor V Korobko
author_sort	Svetlana V Kalinichenko
title	Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.
title_short	Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.
title_full	Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.
title_fullStr	Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.
title_full_unstemmed	Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.
title_sort	identification of nedd4 e3 ubiquitin ligase as a binding partner and regulator of mak-v protein kinase.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/384c65e2d6b54befaad2724241647885
work_keys_str_mv	AT svetlanavkalinichenko identificationofnedd4e3ubiquitinligaseasabindingpartnerandregulatorofmakvproteinkinase AT keijiitoh identificationofnedd4e3ubiquitinligaseasabindingpartnerandregulatorofmakvproteinkinase AT elenavkorobko identificationofnedd4e3ubiquitinligaseasabindingpartnerandregulatorofmakvproteinkinase AT sergeiysokol identificationofnedd4e3ubiquitinligaseasabindingpartnerandregulatorofmakvproteinkinase AT vladimirlbuchman identificationofnedd4e3ubiquitinligaseasabindingpartnerandregulatorofmakvproteinkinase AT igorvkorobko identificationofnedd4e3ubiquitinligaseasabindingpartnerandregulatorofmakvproteinkinase
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Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase.

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