Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model.

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Autores principales:	Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler, Carolin Daniel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/384e9f53afaf4353a75ebc119a70470f
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spelling	oai:doaj.org-article:384e9f53afaf4353a75ebc119a70470f2021-12-02T16:49:58ZType 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice10.1038/ncomms109912041-1723https://doaj.org/article/384e9f53afaf4353a75ebc119a70470f2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10991https://doaj.org/toc/2041-1723Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model.Isabelle SerrRainer W. FürstPeter AchenbachMartin G. SchermFüsun GökmenFlorian HauptEva-Maria SedlmeierAnnette KnopffLeonard ShultzRichard A. WillisAnette-Gabriele ZieglerCarolin DanielNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isabelle Serr Rainer W. Fürst Peter Achenbach Martin G. Scherm Füsun Gökmen Florian Haupt Eva-Maria Sedlmeier Annette Knopff Leonard Shultz Richard A. Willis Anette-Gabriele Ziegler Carolin Daniel Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
description	Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model.
format	article
author	Isabelle Serr Rainer W. Fürst Peter Achenbach Martin G. Scherm Füsun Gökmen Florian Haupt Eva-Maria Sedlmeier Annette Knopff Leonard Shultz Richard A. Willis Anette-Gabriele Ziegler Carolin Daniel
author_facet	Isabelle Serr Rainer W. Fürst Peter Achenbach Martin G. Scherm Füsun Gökmen Florian Haupt Eva-Maria Sedlmeier Annette Knopff Leonard Shultz Richard A. Willis Anette-Gabriele Ziegler Carolin Daniel
author_sort	Isabelle Serr
title	Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_short	Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_full	Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_fullStr	Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_full_unstemmed	Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
title_sort	type 1 diabetes vaccine candidates promote human foxp3+treg induction in humanized mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/384e9f53afaf4353a75ebc119a70470f
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Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

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