CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS

Abstract. Conformational changes of human serum γ–globulin during interaction with the zinc ions were studied in a solution. It has been shown that the presence of zinc in over its physiological concentrations led to increase in optical density across the whole spectrum of γ–globulin ultraviolet abs...

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Autores principales:	S. B. Cheknev, E. E. Babaeva, U. A. Vorobieva, E. A. Denisova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	γ-globulin zinc changes in conformation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/38515fc521174b71bfbe08ee0b220517
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spelling	oai:doaj.org-article:38515fc521174b71bfbe08ee0b2205172021-11-18T08:03:42ZCONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS1563-06252313-741X10.15789/1563-0625-2005-4-375-380https://doaj.org/article/38515fc521174b71bfbe08ee0b2205172014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/486https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Conformational changes of human serum γ–globulin during interaction with the zinc ions were studied in a solution. It has been shown that the presence of zinc in over its physiological concentrations led to increase in optical density across the whole spectrum of γ–globulin ultraviolet absorption. On the contrary, hypochromia in the spectrum was registered after interaction of the protein with zinc used in subphisiological concentrations. Possible role of divalent metal cations in changes in conformation of the blood serum γ–globulins, and thereby in regulation of their effector functions was discussed. (Med. Immunol., 2005, vol.7, № 4, pp. 375–380)S. B. CheknevE. E. BabaevaU. A. VorobievaE. A. DenisovaSPb RAACIarticleγ-globulinzincchanges in conformationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 4, Pp 375-380 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	γ-globulin zinc changes in conformation Immunologic diseases. Allergy RC581-607
spellingShingle	γ-globulin zinc changes in conformation Immunologic diseases. Allergy RC581-607 S. B. Cheknev E. E. Babaeva U. A. Vorobieva E. A. Denisova CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS
description	Abstract. Conformational changes of human serum γ–globulin during interaction with the zinc ions were studied in a solution. It has been shown that the presence of zinc in over its physiological concentrations led to increase in optical density across the whole spectrum of γ–globulin ultraviolet absorption. On the contrary, hypochromia in the spectrum was registered after interaction of the protein with zinc used in subphisiological concentrations. Possible role of divalent metal cations in changes in conformation of the blood serum γ–globulins, and thereby in regulation of their effector functions was discussed. (Med. Immunol., 2005, vol.7, № 4, pp. 375–380)
format	article
author	S. B. Cheknev E. E. Babaeva U. A. Vorobieva E. A. Denisova
author_facet	S. B. Cheknev E. E. Babaeva U. A. Vorobieva E. A. Denisova
author_sort	S. B. Cheknev
title	CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS
title_short	CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS
title_full	CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS
title_fullStr	CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS
title_full_unstemmed	CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS
title_sort	conformation changes of human serum γ–globulin in the presence of zinc ions
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/38515fc521174b71bfbe08ee0b220517
work_keys_str_mv	AT sbcheknev conformationchangesofhumanserumgglobulininthepresenceofzincions AT eebabaeva conformationchangesofhumanserumgglobulininthepresenceofzincions AT uavorobieva conformationchangesofhumanserumgglobulininthepresenceofzincions AT eadenisova conformationchangesofhumanserumgglobulininthepresenceofzincions
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CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS

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