M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole

Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al. show that KIF24 recruits MMP9 to the mother centriole, where it regulates ciliogenesis by controlling CP110-CEP97 recruitment.

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Autores principales:	Ning Huang, Donghui Zhang, Fangyuan Li, Peiyuan Chai, Song Wang, Junlin Teng, Jianguo Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3851be7caf844f9d8bb1fd9d182b4b48
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spelling	oai:doaj.org-article:3851be7caf844f9d8bb1fd9d182b4b482021-12-02T16:56:59ZM-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole10.1038/s41467-018-06990-92041-1723https://doaj.org/article/3851be7caf844f9d8bb1fd9d182b4b482018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06990-9https://doaj.org/toc/2041-1723Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al. show that KIF24 recruits MMP9 to the mother centriole, where it regulates ciliogenesis by controlling CP110-CEP97 recruitment.Ning HuangDonghui ZhangFangyuan LiPeiyuan ChaiSong WangJunlin TengJianguo ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ning Huang Donghui Zhang Fangyuan Li Peiyuan Chai Song Wang Junlin Teng Jianguo Chen M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
description	Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al. show that KIF24 recruits MMP9 to the mother centriole, where it regulates ciliogenesis by controlling CP110-CEP97 recruitment.
format	article
author	Ning Huang Donghui Zhang Fangyuan Li Peiyuan Chai Song Wang Junlin Teng Jianguo Chen
author_facet	Ning Huang Donghui Zhang Fangyuan Li Peiyuan Chai Song Wang Junlin Teng Jianguo Chen
author_sort	Ning Huang
title	M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_short	M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_full	M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_fullStr	M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_full_unstemmed	M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
title_sort	m-phase phosphoprotein 9 regulates ciliogenesis by modulating cp110-cep97 complex localization at the mother centriole
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3851be7caf844f9d8bb1fd9d182b4b48
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M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole

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