Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

APE1 plays an important role in the cellular response to oxidative stress, and mutations are linked to tumor progression and chemoresistance. Here, the authors characterize the interactions of APE1 with RNA and demonstrate a role in microRNA processing.

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Autores principales: Giulia Antoniali, Fabrizio Serra, Lisa Lirussi, Mikiei Tanaka, Chiara D’Ambrosio, Shiheng Zhang, Slobodanka Radovic, Emiliano Dalla, Yari Ciani, Andrea Scaloni, Mengxia Li, Silvano Piazza, Gianluca Tell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3855a9e64787409080f3783d9a0d01ec
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spelling oai:doaj.org-article:3855a9e64787409080f3783d9a0d01ec2021-12-02T14:42:35ZMammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism10.1038/s41467-017-00842-82041-1723https://doaj.org/article/3855a9e64787409080f3783d9a0d01ec2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00842-8https://doaj.org/toc/2041-1723APE1 plays an important role in the cellular response to oxidative stress, and mutations are linked to tumor progression and chemoresistance. Here, the authors characterize the interactions of APE1 with RNA and demonstrate a role in microRNA processing.Giulia AntonialiFabrizio SerraLisa LirussiMikiei TanakaChiara D’AmbrosioShiheng ZhangSlobodanka RadovicEmiliano DallaYari CianiAndrea ScaloniMengxia LiSilvano PiazzaGianluca TellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Giulia Antoniali
Fabrizio Serra
Lisa Lirussi
Mikiei Tanaka
Chiara D’Ambrosio
Shiheng Zhang
Slobodanka Radovic
Emiliano Dalla
Yari Ciani
Andrea Scaloni
Mengxia Li
Silvano Piazza
Gianluca Tell
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
description APE1 plays an important role in the cellular response to oxidative stress, and mutations are linked to tumor progression and chemoresistance. Here, the authors characterize the interactions of APE1 with RNA and demonstrate a role in microRNA processing.
format article
author Giulia Antoniali
Fabrizio Serra
Lisa Lirussi
Mikiei Tanaka
Chiara D’Ambrosio
Shiheng Zhang
Slobodanka Radovic
Emiliano Dalla
Yari Ciani
Andrea Scaloni
Mengxia Li
Silvano Piazza
Gianluca Tell
author_facet Giulia Antoniali
Fabrizio Serra
Lisa Lirussi
Mikiei Tanaka
Chiara D’Ambrosio
Shiheng Zhang
Slobodanka Radovic
Emiliano Dalla
Yari Ciani
Andrea Scaloni
Mengxia Li
Silvano Piazza
Gianluca Tell
author_sort Giulia Antoniali
title Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
title_short Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
title_full Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
title_fullStr Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
title_full_unstemmed Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
title_sort mammalian ape1 controls mirna processing and its interactome is linked to cancer rna metabolism
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/3855a9e64787409080f3783d9a0d01ec
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