Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives

During collective cell migration, how leader cells emerge is poorly understood. Here, the authors find that small groups of mechanically-interacting follower cells pull on the future leaders to stochastically elect them to their fate.

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Autores principales:	Medhavi Vishwakarma, Jacopo Di Russo, Dimitri Probst, Ulrich S. Schwarz, Tamal Das, Joachim P. Spatz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38574b3a8a5f494cb3fa2b88cbb8232c
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spelling	oai:doaj.org-article:38574b3a8a5f494cb3fa2b88cbb8232c2021-12-02T17:31:14ZMechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives10.1038/s41467-018-05927-62041-1723https://doaj.org/article/38574b3a8a5f494cb3fa2b88cbb8232c2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05927-6https://doaj.org/toc/2041-1723During collective cell migration, how leader cells emerge is poorly understood. Here, the authors find that small groups of mechanically-interacting follower cells pull on the future leaders to stochastically elect them to their fate.Medhavi VishwakarmaJacopo Di RussoDimitri ProbstUlrich S. SchwarzTamal DasJoachim P. SpatzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Medhavi Vishwakarma Jacopo Di Russo Dimitri Probst Ulrich S. Schwarz Tamal Das Joachim P. Spatz Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives
description	During collective cell migration, how leader cells emerge is poorly understood. Here, the authors find that small groups of mechanically-interacting follower cells pull on the future leaders to stochastically elect them to their fate.
format	article
author	Medhavi Vishwakarma Jacopo Di Russo Dimitri Probst Ulrich S. Schwarz Tamal Das Joachim P. Spatz
author_facet	Medhavi Vishwakarma Jacopo Di Russo Dimitri Probst Ulrich S. Schwarz Tamal Das Joachim P. Spatz
author_sort	Medhavi Vishwakarma
title	Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives
title_short	Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives
title_full	Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives
title_fullStr	Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives
title_full_unstemmed	Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives
title_sort	mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/38574b3a8a5f494cb3fa2b88cbb8232c
work_keys_str_mv	AT medhavivishwakarma mechanicalinteractionsamongfollowersdeterminetheemergenceofleadersinmigratingepithelialcellcollectives AT jacopodirusso mechanicalinteractionsamongfollowersdeterminetheemergenceofleadersinmigratingepithelialcellcollectives AT dimitriprobst mechanicalinteractionsamongfollowersdeterminetheemergenceofleadersinmigratingepithelialcellcollectives AT ulrichsschwarz mechanicalinteractionsamongfollowersdeterminetheemergenceofleadersinmigratingepithelialcellcollectives AT tamaldas mechanicalinteractionsamongfollowersdeterminetheemergenceofleadersinmigratingepithelialcellcollectives AT joachimpspatz mechanicalinteractionsamongfollowersdeterminetheemergenceofleadersinmigratingepithelialcellcollectives
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Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives

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