Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives

During collective cell migration, how leader cells emerge is poorly understood. Here, the authors find that small groups of mechanically-interacting follower cells pull on the future leaders to stochastically elect them to their fate.

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Autores principales: Medhavi Vishwakarma, Jacopo Di Russo, Dimitri Probst, Ulrich S. Schwarz, Tamal Das, Joachim P. Spatz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/38574b3a8a5f494cb3fa2b88cbb8232c
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