Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives

During collective cell migration, how leader cells emerge is poorly understood. Here, the authors find that small groups of mechanically-interacting follower cells pull on the future leaders to stochastically elect them to their fate.

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Auteurs principaux: Medhavi Vishwakarma, Jacopo Di Russo, Dimitri Probst, Ulrich S. Schwarz, Tamal Das, Joachim P. Spatz
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/38574b3a8a5f494cb3fa2b88cbb8232c
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