Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma

Osteosarcoma is known to have a high metastatic potential, which is closely related to angiogenesis. circRNAs are closely associated with osteosarcoma metastasis. This study aims to investigate the role of Circular RNA circFOXP1 in angiogenesis in osteosarcoma. We detected circFOXP1 expression in os...

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Autores principales:	Haiping Zhang, Ziliang Yu, Bingbing Wu, Farui Sun
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	circfoxp1 mir-127-5p cdkn2aip angiogenesis osteosarcoma Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/385a898e82304ea0a4a82ab5586109a9
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id	oai:doaj.org-article:385a898e82304ea0a4a82ab5586109a9
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spelling	oai:doaj.org-article:385a898e82304ea0a4a82ab5586109a92021-12-01T14:41:00ZCircular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma2165-59792165-598710.1080/21655979.2021.1989258https://doaj.org/article/385a898e82304ea0a4a82ab5586109a92021-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1989258https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Osteosarcoma is known to have a high metastatic potential, which is closely related to angiogenesis. circRNAs are closely associated with osteosarcoma metastasis. This study aims to investigate the role of Circular RNA circFOXP1 in angiogenesis in osteosarcoma. We detected circFOXP1 expression in osteosarcoma, as well as its prognostic value. Tube formation assay and immunohistochemistry staining were conducted to determine the condition of tube formation. RT-qPCR was performed to explore targeted genes. Luciferase reporter assays were carried out to explore the interaction between miR-127-5p, ircFOXP1, and CDKN2AIP, respectively. In vivo studies further confirmed the relationship between circFOXP1 and tumor angiogenesis in osteosarcoma. We found that circFOXP1 expression was increased in osteosarcoma, and could promote angiogenesis in osteosarcoma through upregulating CDKN2AIP expression. Moreover, circFOXP1 could directly bind to miR-127-5p, which further targets CDKN2AIP directly. In conclusion, circFOXP1 promoted angiogenesis by regulating miR-127-5p/CDKN2AIP signaling pathway in osteosarcoma.Haiping ZhangZiliang YuBingbing WuFarui SunTaylor & Francis Grouparticlecircfoxp1mir-127-5pcdkn2aipangiogenesisosteosarcomaBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 2, Pp 9991-9999 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circfoxp1 mir-127-5p cdkn2aip angiogenesis osteosarcoma Biotechnology TP248.13-248.65
spellingShingle	circfoxp1 mir-127-5p cdkn2aip angiogenesis osteosarcoma Biotechnology TP248.13-248.65 Haiping Zhang Ziliang Yu Bingbing Wu Farui Sun Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma
description	Osteosarcoma is known to have a high metastatic potential, which is closely related to angiogenesis. circRNAs are closely associated with osteosarcoma metastasis. This study aims to investigate the role of Circular RNA circFOXP1 in angiogenesis in osteosarcoma. We detected circFOXP1 expression in osteosarcoma, as well as its prognostic value. Tube formation assay and immunohistochemistry staining were conducted to determine the condition of tube formation. RT-qPCR was performed to explore targeted genes. Luciferase reporter assays were carried out to explore the interaction between miR-127-5p, ircFOXP1, and CDKN2AIP, respectively. In vivo studies further confirmed the relationship between circFOXP1 and tumor angiogenesis in osteosarcoma. We found that circFOXP1 expression was increased in osteosarcoma, and could promote angiogenesis in osteosarcoma through upregulating CDKN2AIP expression. Moreover, circFOXP1 could directly bind to miR-127-5p, which further targets CDKN2AIP directly. In conclusion, circFOXP1 promoted angiogenesis by regulating miR-127-5p/CDKN2AIP signaling pathway in osteosarcoma.
format	article
author	Haiping Zhang Ziliang Yu Bingbing Wu Farui Sun
author_facet	Haiping Zhang Ziliang Yu Bingbing Wu Farui Sun
author_sort	Haiping Zhang
title	Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma
title_short	Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma
title_full	Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma
title_fullStr	Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma
title_full_unstemmed	Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma
title_sort	circular rna circfoxp1 promotes angiogenesis by regulating microrna -127-5p/cdkn2aip signaling pathway in osteosarcoma
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/385a898e82304ea0a4a82ab5586109a9
work_keys_str_mv	AT haipingzhang circularrnacircfoxp1promotesangiogenesisbyregulatingmicrorna1275pcdkn2aipsignalingpathwayinosteosarcoma AT ziliangyu circularrnacircfoxp1promotesangiogenesisbyregulatingmicrorna1275pcdkn2aipsignalingpathwayinosteosarcoma AT bingbingwu circularrnacircfoxp1promotesangiogenesisbyregulatingmicrorna1275pcdkn2aipsignalingpathwayinosteosarcoma AT faruisun circularrnacircfoxp1promotesangiogenesisbyregulatingmicrorna1275pcdkn2aipsignalingpathwayinosteosarcoma
_version_	1718404985202409472

Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma

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