Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis

In the article was studied the effects of flavonol quercetin on indices of adaptive immune response in experimental animals on the 14th day of the experimental bacterial-immune periodontitis development. Indices of immune protection were determined by the relative number of lymphocytes with CD3+, CD...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrii Demkovych, Yurii Bondarenko, Vitaliy Shcherba, Vitalii Luchynskyi, Volodymyr Vitkovskyy, Volodymyr Machogan
Formato:	article
Lenguaje:	EN
Publicado:	Pensoft Publishers 2021
Materias:	Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/385aea1acae4422dbb89b332abc089df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:385aea1acae4422dbb89b332abc089df
record_format	dspace
spelling	oai:doaj.org-article:385aea1acae4422dbb89b332abc089df2021-11-20T04:30:25ZQuercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis10.3897/pharmacia.68.e708832603-557Xhttps://doaj.org/article/385aea1acae4422dbb89b332abc089df2021-11-01T00:00:00Zhttps://pharmacia.pensoft.net/article/70883/download/pdf/https://pharmacia.pensoft.net/article/70883/download/xml/https://pharmacia.pensoft.net/article/70883/https://doaj.org/toc/2603-557XIn the article was studied the effects of flavonol quercetin on indices of adaptive immune response in experimental animals on the 14th day of the experimental bacterial-immune periodontitis development. Indices of immune protection were determined by the relative number of lymphocytes with CD3+, CD4+, CD8+, CD19+, CD16+ and immunoregulatory index (CD4+ / CD8+) in intact animals and on the 14th day of inflammatory process development in periodontal tissues as well as the therapeutic effects of flavonol quercetin. As a result of the study, characterized changes associated with the activity of both the cell-mediated and humoral-immune response were found, both in the development of experimental periodontitis, and apply of flavonol. In particular, there was an increase in the animal’s blood relative amount of CD8+, CD16+ cells on the 14th day, and content of CD3+, CD4+, CD19+ was decreased. In this case, the immunoregulatory index (CD4+ / CD8+) as an important index of immunological activity was decreased. The apply of flavonol quercetin in the period development of bacterial-immune periodontitis animals functional activity of the T-cell line of the immune system was increased, as evidenced percentage increase of B- and T-cells due to T-helper cells decrease as well as T-killers content during this period of inflammatory reaction in the periodontal complex, in comparison with animals, which were not treated.Andrii DemkovychYurii BondarenkoVitaliy ShcherbaVitalii LuchynskyiVolodymyr VitkovskyyVolodymyr MachoganPensoft PublishersarticlePharmacy and materia medicaRS1-441ENPharmacia, Vol 68, Iss 4, Pp 877-882 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pharmacy and materia medica RS1-441
spellingShingle	Pharmacy and materia medica RS1-441 Andrii Demkovych Yurii Bondarenko Vitaliy Shcherba Vitalii Luchynskyi Volodymyr Vitkovskyy Volodymyr Machogan Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis
description	In the article was studied the effects of flavonol quercetin on indices of adaptive immune response in experimental animals on the 14th day of the experimental bacterial-immune periodontitis development. Indices of immune protection were determined by the relative number of lymphocytes with CD3+, CD4+, CD8+, CD19+, CD16+ and immunoregulatory index (CD4+ / CD8+) in intact animals and on the 14th day of inflammatory process development in periodontal tissues as well as the therapeutic effects of flavonol quercetin. As a result of the study, characterized changes associated with the activity of both the cell-mediated and humoral-immune response were found, both in the development of experimental periodontitis, and apply of flavonol. In particular, there was an increase in the animal’s blood relative amount of CD8+, CD16+ cells on the 14th day, and content of CD3+, CD4+, CD19+ was decreased. In this case, the immunoregulatory index (CD4+ / CD8+) as an important index of immunological activity was decreased. The apply of flavonol quercetin in the period development of bacterial-immune periodontitis animals functional activity of the T-cell line of the immune system was increased, as evidenced percentage increase of B- and T-cells due to T-helper cells decrease as well as T-killers content during this period of inflammatory reaction in the periodontal complex, in comparison with animals, which were not treated.
format	article
author	Andrii Demkovych Yurii Bondarenko Vitaliy Shcherba Vitalii Luchynskyi Volodymyr Vitkovskyy Volodymyr Machogan
author_facet	Andrii Demkovych Yurii Bondarenko Vitaliy Shcherba Vitalii Luchynskyi Volodymyr Vitkovskyy Volodymyr Machogan
author_sort	Andrii Demkovych
title	Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis
title_short	Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis
title_full	Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis
title_fullStr	Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis
title_full_unstemmed	Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis
title_sort	quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis
publisher	Pensoft Publishers
publishDate	2021
url	https://doaj.org/article/385aea1acae4422dbb89b332abc089df
work_keys_str_mv	AT andriidemkovych quercetineffectsonadaptiveimmuneresponseinexperimentalperiodontitisofbacterialimmunegenesis AT yuriibondarenko quercetineffectsonadaptiveimmuneresponseinexperimentalperiodontitisofbacterialimmunegenesis AT vitaliyshcherba quercetineffectsonadaptiveimmuneresponseinexperimentalperiodontitisofbacterialimmunegenesis AT vitaliiluchynskyi quercetineffectsonadaptiveimmuneresponseinexperimentalperiodontitisofbacterialimmunegenesis AT volodymyrvitkovskyy quercetineffectsonadaptiveimmuneresponseinexperimentalperiodontitisofbacterialimmunegenesis AT volodymyrmachogan quercetineffectsonadaptiveimmuneresponseinexperimentalperiodontitisofbacterialimmunegenesis
_version_	1718419766896492544

Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis

Ejemplares similares