Spatiotemporal expression of IgLON family members in the developing mouse nervous system

Abstract Differential expression of cell adhesion molecules in neuronal populations is one of the many mechanisms promoting the formation of functional neural circuits in the developing nervous system. The IgLON family consists of five cell surface immunoglobulin proteins that have been associated w...

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Autores principales:	Sydney Fearnley, Reesha Raja, Jean-François Cloutier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/385c10597efb4de58484bf1fc274648f
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spelling	oai:doaj.org-article:385c10597efb4de58484bf1fc274648f2021-12-02T18:51:07ZSpatiotemporal expression of IgLON family members in the developing mouse nervous system10.1038/s41598-021-97768-52045-2322https://doaj.org/article/385c10597efb4de58484bf1fc274648f2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97768-5https://doaj.org/toc/2045-2322Abstract Differential expression of cell adhesion molecules in neuronal populations is one of the many mechanisms promoting the formation of functional neural circuits in the developing nervous system. The IgLON family consists of five cell surface immunoglobulin proteins that have been associated with various developmental disorders, such as autism spectrum disorder, schizophrenia, and major depressive disorder. However, there is still limited and fragmented information about their patterns of expression in certain regions of the developing nervous system and how their expression contributes to their function. Utilizing an in situ hybridization approach, we have analyzed the spatiotemporal expression of all IgLON family members in the developing mouse brain, spinal cord, eye, olfactory epithelium, and vomeronasal organ. At one prenatal (E16) and two postnatal (P0 and P15) ages, we show that each IgLON displays distinct expression patterns in the olfactory system, cerebral cortex, midbrain, cerebellum, spinal cord, and eye, indicating that they likely contribute to the wiring of specific neuronal circuitry. These analyses will inform future functional studies aimed at identifying additional roles for these proteins in nervous system development.Sydney FearnleyReesha RajaJean-François CloutierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sydney Fearnley Reesha Raja Jean-François Cloutier Spatiotemporal expression of IgLON family members in the developing mouse nervous system
description	Abstract Differential expression of cell adhesion molecules in neuronal populations is one of the many mechanisms promoting the formation of functional neural circuits in the developing nervous system. The IgLON family consists of five cell surface immunoglobulin proteins that have been associated with various developmental disorders, such as autism spectrum disorder, schizophrenia, and major depressive disorder. However, there is still limited and fragmented information about their patterns of expression in certain regions of the developing nervous system and how their expression contributes to their function. Utilizing an in situ hybridization approach, we have analyzed the spatiotemporal expression of all IgLON family members in the developing mouse brain, spinal cord, eye, olfactory epithelium, and vomeronasal organ. At one prenatal (E16) and two postnatal (P0 and P15) ages, we show that each IgLON displays distinct expression patterns in the olfactory system, cerebral cortex, midbrain, cerebellum, spinal cord, and eye, indicating that they likely contribute to the wiring of specific neuronal circuitry. These analyses will inform future functional studies aimed at identifying additional roles for these proteins in nervous system development.
format	article
author	Sydney Fearnley Reesha Raja Jean-François Cloutier
author_facet	Sydney Fearnley Reesha Raja Jean-François Cloutier
author_sort	Sydney Fearnley
title	Spatiotemporal expression of IgLON family members in the developing mouse nervous system
title_short	Spatiotemporal expression of IgLON family members in the developing mouse nervous system
title_full	Spatiotemporal expression of IgLON family members in the developing mouse nervous system
title_fullStr	Spatiotemporal expression of IgLON family members in the developing mouse nervous system
title_full_unstemmed	Spatiotemporal expression of IgLON family members in the developing mouse nervous system
title_sort	spatiotemporal expression of iglon family members in the developing mouse nervous system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/385c10597efb4de58484bf1fc274648f
work_keys_str_mv	AT sydneyfearnley spatiotemporalexpressionofiglonfamilymembersinthedevelopingmousenervoussystem AT reesharaja spatiotemporalexpressionofiglonfamilymembersinthedevelopingmousenervoussystem AT jeanfrancoiscloutier spatiotemporalexpressionofiglonfamilymembersinthedevelopingmousenervoussystem
_version_	1718377439888932864

Spatiotemporal expression of IgLON family members in the developing mouse nervous system

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