IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and activates survival metabolic changes mediated...

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Autores principales:	Chiara Montemurro, Hiroshi Nomoto, Lina Pei, Vishal S. Parekh, Kenny E. Vongbunyong, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E. Butler, Rohan Subramaniam, Eleni Ritou, Orian S. Shirihai, Leslie S. Satin, Peter C. Butler, Slavica Tudzarova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/386002cb2bd14399b8b10d3e7c881ca5
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spelling	oai:doaj.org-article:386002cb2bd14399b8b10d3e7c881ca52021-12-02T16:57:19ZIAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function10.1038/s41467-019-10444-12041-1723https://doaj.org/article/386002cb2bd14399b8b10d3e7c881ca52019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10444-1https://doaj.org/toc/2041-1723Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and activates survival metabolic changes mediated by PFKFB3.Chiara MontemurroHiroshi NomotoLina PeiVishal S. ParekhKenny E. VongbunyongSuryakiran VadrevuTatyana GurloAlexandra E. ButlerRohan SubramaniamEleni RitouOrian S. ShirihaiLeslie S. SatinPeter C. ButlerSlavica TudzarovaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiara Montemurro Hiroshi Nomoto Lina Pei Vishal S. Parekh Kenny E. Vongbunyong Suryakiran Vadrevu Tatyana Gurlo Alexandra E. Butler Rohan Subramaniam Eleni Ritou Orian S. Shirihai Leslie S. Satin Peter C. Butler Slavica Tudzarova IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
description	Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and activates survival metabolic changes mediated by PFKFB3.
format	article
author	Chiara Montemurro Hiroshi Nomoto Lina Pei Vishal S. Parekh Kenny E. Vongbunyong Suryakiran Vadrevu Tatyana Gurlo Alexandra E. Butler Rohan Subramaniam Eleni Ritou Orian S. Shirihai Leslie S. Satin Peter C. Butler Slavica Tudzarova
author_facet	Chiara Montemurro Hiroshi Nomoto Lina Pei Vishal S. Parekh Kenny E. Vongbunyong Suryakiran Vadrevu Tatyana Gurlo Alexandra E. Butler Rohan Subramaniam Eleni Ritou Orian S. Shirihai Leslie S. Satin Peter C. Butler Slavica Tudzarova
author_sort	Chiara Montemurro
title	IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
title_short	IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
title_full	IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
title_fullStr	IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
title_full_unstemmed	IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
title_sort	iapp toxicity activates hif1α/pfkfb3 signaling delaying β-cell loss at the expense of β-cell function
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/386002cb2bd14399b8b10d3e7c881ca5
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IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

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