IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and activates survival metabolic changes mediated...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chiara Montemurro, Hiroshi Nomoto, Lina Pei, Vishal S. Parekh, Kenny E. Vongbunyong, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E. Butler, Rohan Subramaniam, Eleni Ritou, Orian S. Shirihai, Leslie S. Satin, Peter C. Butler, Slavica Tudzarova
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/386002cb2bd14399b8b10d3e7c881ca5
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Documents similaires