DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY

Objective: To find the effect of dexmedetomidine on acute post-operative analgesia and on postoperative opioid requirement. Study Design: Quasi experimental study. Place and Duration of Study: The study was conducted at department of Anaesthesia and Intensive care, CMH Rawalpindi, from Jan 201...

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Autores principales:	Liaquat Ali, Waqas Alam, Umer Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	acute postoperative pain dexmedetomidine nalbuphine Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3860d675a87248e0abc70774a80f712f
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spelling	oai:doaj.org-article:3860d675a87248e0abc70774a80f712f2021-11-08T05:14:02ZDEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY0030-96482411-8842https://doaj.org/article/3860d675a87248e0abc70774a80f712f2019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3388/2365https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To find the effect of dexmedetomidine on acute post-operative analgesia and on postoperative opioid requirement. Study Design: Quasi experimental study. Place and Duration of Study: The study was conducted at department of Anaesthesia and Intensive care, CMH Rawalpindi, from Jan 2015 to Oct 2015. Methodology: In this study 80 patients were divided in two equal groups. Group A was controlled group in which saline infusion was used and Group B was study group in which dexmedetomidine infusion was used. Both groups were anesthetized with similar technique and were given nalbuphine 0.1mg/kg in the beginning. Group B was started dexmedetomidine almost half hour before end of procedure and group A was given normal saline. Infusion of dexmedetomidine continued for 8 hours postoperatively. Rescue nalbuphine of 0.05mg/kg was given in both groups when visual analogue scale score was 3 or more. Results: Eighty patients including 48 (60%) males and 32 (40%) females were enrolled in study. In group A loading dose of nalbuphine was 7.02 ± 0.76 mg and in group B it was 6.93 ± 1.00 mg. Mean loading dose of dexmedetomidine was 32.98 ± 9.11μg. Mean Dexmedetomidine given in infusion was 105.56 ± 29.16 μg. There was significant decrease in VAS score in group B. In group A total postoperative nalbuphine used was 8.13 ± 2.86 mg and in dexmedetomidine group total nalbuphine used was 5.01 ± 1.93 mg. The p-value was 0.001 which was significant. Conclusion: Use of dexmedetomidine resulted in reduced acute postoperative pain as shown by better visual analogue scale profile. It also resulted in reduced opioid requirement in postoperative period. We suggest that studies should be done which also include these factors and have large sample size so results can be generalized on population.Liaquat AliWaqas AlamUmer AliArmy Medical College Rawalpindiarticleacute postoperative paindexmedetomidinenalbuphineMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 934-938 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute postoperative pain dexmedetomidine nalbuphine Medicine R Medicine (General) R5-920
spellingShingle	acute postoperative pain dexmedetomidine nalbuphine Medicine R Medicine (General) R5-920 Liaquat Ali Waqas Alam Umer Ali DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY
description	Objective: To find the effect of dexmedetomidine on acute post-operative analgesia and on postoperative opioid requirement. Study Design: Quasi experimental study. Place and Duration of Study: The study was conducted at department of Anaesthesia and Intensive care, CMH Rawalpindi, from Jan 2015 to Oct 2015. Methodology: In this study 80 patients were divided in two equal groups. Group A was controlled group in which saline infusion was used and Group B was study group in which dexmedetomidine infusion was used. Both groups were anesthetized with similar technique and were given nalbuphine 0.1mg/kg in the beginning. Group B was started dexmedetomidine almost half hour before end of procedure and group A was given normal saline. Infusion of dexmedetomidine continued for 8 hours postoperatively. Rescue nalbuphine of 0.05mg/kg was given in both groups when visual analogue scale score was 3 or more. Results: Eighty patients including 48 (60%) males and 32 (40%) females were enrolled in study. In group A loading dose of nalbuphine was 7.02 ± 0.76 mg and in group B it was 6.93 ± 1.00 mg. Mean loading dose of dexmedetomidine was 32.98 ± 9.11μg. Mean Dexmedetomidine given in infusion was 105.56 ± 29.16 μg. There was significant decrease in VAS score in group B. In group A total postoperative nalbuphine used was 8.13 ± 2.86 mg and in dexmedetomidine group total nalbuphine used was 5.01 ± 1.93 mg. The p-value was 0.001 which was significant. Conclusion: Use of dexmedetomidine resulted in reduced acute postoperative pain as shown by better visual analogue scale profile. It also resulted in reduced opioid requirement in postoperative period. We suggest that studies should be done which also include these factors and have large sample size so results can be generalized on population.
format	article
author	Liaquat Ali Waqas Alam Umer Ali
author_facet	Liaquat Ali Waqas Alam Umer Ali
author_sort	Liaquat Ali
title	DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY
title_short	DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY
title_full	DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY
title_fullStr	DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY
title_full_unstemmed	DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY
title_sort	dexmedetomidine for acute postoperative analgesia in patients undergoing laparotomy
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/3860d675a87248e0abc70774a80f712f
work_keys_str_mv	AT liaquatali dexmedetomidineforacutepostoperativeanalgesiainpatientsundergoinglaparotomy AT waqasalam dexmedetomidineforacutepostoperativeanalgesiainpatientsundergoinglaparotomy AT umerali dexmedetomidineforacutepostoperativeanalgesiainpatientsundergoinglaparotomy
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DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY

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