Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development

The expression of CD4, a critical co-receptor providing T cell help in adaptive immunity, is finely tuned during development. Here the authors show that two enhancer elements, E4p and the newly-defined E4m, coordinate the expression and heritable demethylation of Cd4 in thymocytes but are dispensabl...

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Autores principales:	Priya D. Issuree, Kenneth Day, Christy Au, Ramya Raviram, Paul Zappile, Jane A. Skok, Hai-Hui Xue, Richard M. Myers, Dan R. Littman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38633a03487a452189662a07b1d1c11b
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spelling	oai:doaj.org-article:38633a03487a452189662a07b1d1c11b2021-12-02T14:40:32ZStage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development10.1038/s41467-018-05834-w2041-1723https://doaj.org/article/38633a03487a452189662a07b1d1c11b2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05834-whttps://doaj.org/toc/2041-1723The expression of CD4, a critical co-receptor providing T cell help in adaptive immunity, is finely tuned during development. Here the authors show that two enhancer elements, E4p and the newly-defined E4m, coordinate the expression and heritable demethylation of Cd4 in thymocytes but are dispensable for its sustained expression in peripheral T cells.Priya D. IssureeKenneth DayChristy AuRamya RaviramPaul ZappileJane A. SkokHai-Hui XueRichard M. MyersDan R. LittmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Priya D. Issuree Kenneth Day Christy Au Ramya Raviram Paul Zappile Jane A. Skok Hai-Hui Xue Richard M. Myers Dan R. Littman Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
description	The expression of CD4, a critical co-receptor providing T cell help in adaptive immunity, is finely tuned during development. Here the authors show that two enhancer elements, E4p and the newly-defined E4m, coordinate the expression and heritable demethylation of Cd4 in thymocytes but are dispensable for its sustained expression in peripheral T cells.
format	article
author	Priya D. Issuree Kenneth Day Christy Au Ramya Raviram Paul Zappile Jane A. Skok Hai-Hui Xue Richard M. Myers Dan R. Littman
author_facet	Priya D. Issuree Kenneth Day Christy Au Ramya Raviram Paul Zappile Jane A. Skok Hai-Hui Xue Richard M. Myers Dan R. Littman
author_sort	Priya D. Issuree
title	Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
title_short	Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
title_full	Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
title_fullStr	Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
title_full_unstemmed	Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
title_sort	stage-specific epigenetic regulation of cd4 expression by coordinated enhancer elements during t cell development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/38633a03487a452189662a07b1d1c11b
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Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development

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