Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development

The expression of CD4, a critical co-receptor providing T cell help in adaptive immunity, is finely tuned during development. Here the authors show that two enhancer elements, E4p and the newly-defined E4m, coordinate the expression and heritable demethylation of Cd4 in thymocytes but are dispensabl...

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Autores principales: Priya D. Issuree, Kenneth Day, Christy Au, Ramya Raviram, Paul Zappile, Jane A. Skok, Hai-Hui Xue, Richard M. Myers, Dan R. Littman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/38633a03487a452189662a07b1d1c11b
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