Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features

Abstract Lymphomas involving the mediastinum occur in a wide age range and represent heterogeneous histological subtypes with various clinical symptoms and complex radiological findings. However, studies that describe the clinical and radiological features of different subtypes among Chinese pediatr...

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Autores principales:	Lei Chen, Mingsong Wang, Hua Fan, Fengqing Hu, Tingting Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/38634a82fcbe4b3a9614e757e834fd56
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spelling	oai:doaj.org-article:38634a82fcbe4b3a9614e757e834fd562021-12-02T12:31:50ZComparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features10.1038/s41598-017-02720-12045-2322https://doaj.org/article/38634a82fcbe4b3a9614e757e834fd562017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02720-1https://doaj.org/toc/2045-2322Abstract Lymphomas involving the mediastinum occur in a wide age range and represent heterogeneous histological subtypes with various clinical symptoms and complex radiological findings. However, studies that describe the clinical and radiological features of different subtypes among Chinese pediatric and adult patients are limited. We analyzed the clinical, radiological and pathological features of 31 pediatric lymphomas involving the mediastinum, and compared them to the features of 21 adult patients. Although several histological subtypes were identified in adults, pediatric patients presented with T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia (T-LBL/T-ALL) and classical Hodgkin lymphomas (CHL) in 24 and 7 cases, respectively. Compared to adults, pediatric patients were more likely to be male (P = 0.089) and showed a higher incidence of T-LBL/T-ALL (P = 0.001), prevalence of dyspnea (P = 0.001), frequency of stage IV tumors (P = 0.008), and ratio of tumor diameter to maximum transthoracic diameter (P = 0.015). T-LBL/T-ALL patients presented with a higher frequency with stage IV disease (P = 0.000 and P = 0.001), compression of the blood vessels (P = 0.005 and P = 0.017), and pleural effusions (P = 0.001, for both) than CHL and PMBL patients. Compared to adults, pediatric patients with mediastinal lymphomas presented with exclusive histological subtypes of T-LBL/T-ALL and CHL, which showed distinctive characteristics of histological distribution, clinical presentation and radiological assessments.Lei ChenMingsong WangHua FanFengqing HuTingting LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lei Chen Mingsong Wang Hua Fan Fengqing Hu Tingting Liu Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features
description	Abstract Lymphomas involving the mediastinum occur in a wide age range and represent heterogeneous histological subtypes with various clinical symptoms and complex radiological findings. However, studies that describe the clinical and radiological features of different subtypes among Chinese pediatric and adult patients are limited. We analyzed the clinical, radiological and pathological features of 31 pediatric lymphomas involving the mediastinum, and compared them to the features of 21 adult patients. Although several histological subtypes were identified in adults, pediatric patients presented with T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia (T-LBL/T-ALL) and classical Hodgkin lymphomas (CHL) in 24 and 7 cases, respectively. Compared to adults, pediatric patients were more likely to be male (P = 0.089) and showed a higher incidence of T-LBL/T-ALL (P = 0.001), prevalence of dyspnea (P = 0.001), frequency of stage IV tumors (P = 0.008), and ratio of tumor diameter to maximum transthoracic diameter (P = 0.015). T-LBL/T-ALL patients presented with a higher frequency with stage IV disease (P = 0.000 and P = 0.001), compression of the blood vessels (P = 0.005 and P = 0.017), and pleural effusions (P = 0.001, for both) than CHL and PMBL patients. Compared to adults, pediatric patients with mediastinal lymphomas presented with exclusive histological subtypes of T-LBL/T-ALL and CHL, which showed distinctive characteristics of histological distribution, clinical presentation and radiological assessments.
format	article
author	Lei Chen Mingsong Wang Hua Fan Fengqing Hu Tingting Liu
author_facet	Lei Chen Mingsong Wang Hua Fan Fengqing Hu Tingting Liu
author_sort	Lei Chen
title	Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features
title_short	Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features
title_full	Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features
title_fullStr	Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features
title_full_unstemmed	Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features
title_sort	comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/38634a82fcbe4b3a9614e757e834fd56
work_keys_str_mv	AT leichen comparisonofpediatricandadultlymphomasinvolvingthemediastinumcharacterizedbydistinctiveclinicopathologicalandradiologicalfeatures AT mingsongwang comparisonofpediatricandadultlymphomasinvolvingthemediastinumcharacterizedbydistinctiveclinicopathologicalandradiologicalfeatures AT huafan comparisonofpediatricandadultlymphomasinvolvingthemediastinumcharacterizedbydistinctiveclinicopathologicalandradiologicalfeatures AT fengqinghu comparisonofpediatricandadultlymphomasinvolvingthemediastinumcharacterizedbydistinctiveclinicopathologicalandradiologicalfeatures AT tingtingliu comparisonofpediatricandadultlymphomasinvolvingthemediastinumcharacterizedbydistinctiveclinicopathologicalandradiologicalfeatures
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Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features

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