Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain

Abstract Identification of obstructive coronary artery disease (OCAD) in patients with chest pain is a clinical challenge. The value of corrected QT interval (QTc) for the prediction of OCAD has yet to be established. We consecutively enrolled 1741 patients with suspected angina. The presence of obs...

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Autores principales:	Dong-Hyuk Cho, Jimi Choi, Mi-Na Kim, Hee-Dong Kim, Soon Jun Hong, Cheol Woong Yu, Hack-Lyoung Kim, Yong Hyun Kim, Jin Oh Na, Hyun-Ju Yoon, Mi-Seung Shin, Myung-A Kim, Kyung-Soon Hong, Wan Joo Shim, Seong-Mi Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3863d73f4cc746c9986dcaff8e3bb3e6
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spelling	oai:doaj.org-article:3863d73f4cc746c9986dcaff8e3bb3e62021-12-02T16:51:14ZIncremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain10.1038/s41598-021-90133-62045-2322https://doaj.org/article/3863d73f4cc746c9986dcaff8e3bb3e62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90133-6https://doaj.org/toc/2045-2322Abstract Identification of obstructive coronary artery disease (OCAD) in patients with chest pain is a clinical challenge. The value of corrected QT interval (QTc) for the prediction of OCAD has yet to be established. We consecutively enrolled 1741 patients with suspected angina. The presence of obstructive OCAD was defined as ≥ 50% diameter stenosis by coronary angiography. The pre-test probability was evaluated by combining QTc prolongation with the CAD Consortium clinical score (CAD2) and the updated Diamond-Forrester (UDF) score. OCAD was detected in 661 patients (38.0%). QTc was longer in patients with OCAD compared with those without OCAD (444 ± 34 vs. 429 ± 28 ms, p < 0.001). QTc was increased by the severity of OCAD (P < 0.001). QTc prolongation was associated with OCAD (odds ratio (OR), 2.27; 95% confidence interval (CI), 1.81–2.85). With QTc, the C-statistics increased significantly from 0.68 (95% CI 0.66–0.71) to 0.76 (95% CI 0.74–0.78) in the CAD2 and from 0.64 (95% CI 0.62–0.67) to 0.74 (95% CI 0.72–0.77) in the UDF score, respectively. QT prolongation predicted the presence of OCAD and the QTc improved model performance to predict OCAD compared with CAD2 or UDF scores in patients with suspected angina.Dong-Hyuk ChoJimi ChoiMi-Na KimHee-Dong KimSoon Jun HongCheol Woong YuHack-Lyoung KimYong Hyun KimJin Oh NaHyun-Ju YoonMi-Seung ShinMyung-A KimKyung-Soon HongWan Joo ShimSeong-Mi ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong-Hyuk Cho Jimi Choi Mi-Na Kim Hee-Dong Kim Soon Jun Hong Cheol Woong Yu Hack-Lyoung Kim Yong Hyun Kim Jin Oh Na Hyun-Ju Yoon Mi-Seung Shin Myung-A Kim Kyung-Soon Hong Wan Joo Shim Seong-Mi Park Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain
description	Abstract Identification of obstructive coronary artery disease (OCAD) in patients with chest pain is a clinical challenge. The value of corrected QT interval (QTc) for the prediction of OCAD has yet to be established. We consecutively enrolled 1741 patients with suspected angina. The presence of obstructive OCAD was defined as ≥ 50% diameter stenosis by coronary angiography. The pre-test probability was evaluated by combining QTc prolongation with the CAD Consortium clinical score (CAD2) and the updated Diamond-Forrester (UDF) score. OCAD was detected in 661 patients (38.0%). QTc was longer in patients with OCAD compared with those without OCAD (444 ± 34 vs. 429 ± 28 ms, p < 0.001). QTc was increased by the severity of OCAD (P < 0.001). QTc prolongation was associated with OCAD (odds ratio (OR), 2.27; 95% confidence interval (CI), 1.81–2.85). With QTc, the C-statistics increased significantly from 0.68 (95% CI 0.66–0.71) to 0.76 (95% CI 0.74–0.78) in the CAD2 and from 0.64 (95% CI 0.62–0.67) to 0.74 (95% CI 0.72–0.77) in the UDF score, respectively. QT prolongation predicted the presence of OCAD and the QTc improved model performance to predict OCAD compared with CAD2 or UDF scores in patients with suspected angina.
format	article
author	Dong-Hyuk Cho Jimi Choi Mi-Na Kim Hee-Dong Kim Soon Jun Hong Cheol Woong Yu Hack-Lyoung Kim Yong Hyun Kim Jin Oh Na Hyun-Ju Yoon Mi-Seung Shin Myung-A Kim Kyung-Soon Hong Wan Joo Shim Seong-Mi Park
author_facet	Dong-Hyuk Cho Jimi Choi Mi-Na Kim Hee-Dong Kim Soon Jun Hong Cheol Woong Yu Hack-Lyoung Kim Yong Hyun Kim Jin Oh Na Hyun-Ju Yoon Mi-Seung Shin Myung-A Kim Kyung-Soon Hong Wan Joo Shim Seong-Mi Park
author_sort	Dong-Hyuk Cho
title	Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain
title_short	Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain
title_full	Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain
title_fullStr	Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain
title_full_unstemmed	Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain
title_sort	incremental value of qt interval for the prediction of obstructive coronary artery disease in patients with chest pain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3863d73f4cc746c9986dcaff8e3bb3e6
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Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain

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