Predictive value of clinical judgment of tumour progression in phase II trials.

<h4>Background</h4>The diagnosis of tumour progression or progressive disease (PD) is a key element for designing and interpreting contemporary phase II trials. In some cases, PD is stated by the physician and is not formally confirmed by imaging.<h4>Purpose</h4>In this study...

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Autores principales:	Nuria Kotecki, Nicolas Penel, Antoine Adenis, Charles Ferte, Stéphanie Clisant
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3863f9b65184415893c32d5361af0b0c
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spelling	oai:doaj.org-article:3863f9b65184415893c32d5361af0b0c2021-11-18T08:03:39ZPredictive value of clinical judgment of tumour progression in phase II trials.1932-620310.1371/journal.pone.0052638https://doaj.org/article/3863f9b65184415893c32d5361af0b0c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300731/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The diagnosis of tumour progression or progressive disease (PD) is a key element for designing and interpreting contemporary phase II trials. In some cases, PD is stated by the physician and is not formally confirmed by imaging.<h4>Purpose</h4>In this study, we intend to analyze the value of the PD based on clinical judgment and the risk of overestimating the occurrence of PD by clinical judgment.<h4>Methods</h4>We have conducted a single-centre retrospective study to analyse the diagnostic accuracy of this clinical judgment compared to planned imaging including all patients enrolled in our institution in phase II trials investigating systemic treatments for advanced solid tumours between January 2008 and November 2010.<h4>Results</h4>The positive predictive value (PPV) and the specificity of clinical judgment of PD was very high (>90%).<h4>Conclusions</h4>According to this study, the clinical judgment of PD is highly predictive of radiological PD as assessed, for example, by RECIST. Physicians do not overestimate PD occurence. Clinical judgment of PD could be taken into account in the definition of PD.Nuria KoteckiNicolas PenelAntoine AdenisCharles FerteStéphanie ClisantPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52638 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nuria Kotecki Nicolas Penel Antoine Adenis Charles Ferte Stéphanie Clisant Predictive value of clinical judgment of tumour progression in phase II trials.
description	<h4>Background</h4>The diagnosis of tumour progression or progressive disease (PD) is a key element for designing and interpreting contemporary phase II trials. In some cases, PD is stated by the physician and is not formally confirmed by imaging.<h4>Purpose</h4>In this study, we intend to analyze the value of the PD based on clinical judgment and the risk of overestimating the occurrence of PD by clinical judgment.<h4>Methods</h4>We have conducted a single-centre retrospective study to analyse the diagnostic accuracy of this clinical judgment compared to planned imaging including all patients enrolled in our institution in phase II trials investigating systemic treatments for advanced solid tumours between January 2008 and November 2010.<h4>Results</h4>The positive predictive value (PPV) and the specificity of clinical judgment of PD was very high (>90%).<h4>Conclusions</h4>According to this study, the clinical judgment of PD is highly predictive of radiological PD as assessed, for example, by RECIST. Physicians do not overestimate PD occurence. Clinical judgment of PD could be taken into account in the definition of PD.
format	article
author	Nuria Kotecki Nicolas Penel Antoine Adenis Charles Ferte Stéphanie Clisant
author_facet	Nuria Kotecki Nicolas Penel Antoine Adenis Charles Ferte Stéphanie Clisant
author_sort	Nuria Kotecki
title	Predictive value of clinical judgment of tumour progression in phase II trials.
title_short	Predictive value of clinical judgment of tumour progression in phase II trials.
title_full	Predictive value of clinical judgment of tumour progression in phase II trials.
title_fullStr	Predictive value of clinical judgment of tumour progression in phase II trials.
title_full_unstemmed	Predictive value of clinical judgment of tumour progression in phase II trials.
title_sort	predictive value of clinical judgment of tumour progression in phase ii trials.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3863f9b65184415893c32d5361af0b0c
work_keys_str_mv	AT nuriakotecki predictivevalueofclinicaljudgmentoftumourprogressioninphaseiitrials AT nicolaspenel predictivevalueofclinicaljudgmentoftumourprogressioninphaseiitrials AT antoineadenis predictivevalueofclinicaljudgmentoftumourprogressioninphaseiitrials AT charlesferte predictivevalueofclinicaljudgmentoftumourprogressioninphaseiitrials AT stephanieclisant predictivevalueofclinicaljudgmentoftumourprogressioninphaseiitrials
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Predictive value of clinical judgment of tumour progression in phase II trials.

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