Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.

Although astrocytes are the most abundant cell type in the central nervous system (CNS), little is known about their molecular specification and differentiation. It has previously been reported that transcription factor Nkx6.1 is expressed in neuroepithelial cells that give rise to astrocyte precurs...

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Autores principales:	Xiaofeng Zhao, Yidan Chen, Qiang Zhu, Hao Huang, Peng Teng, Kang Zheng, Xuemei Hu, Binghua Xie, Zunyi Zhang, Maike Sander, Mengsheng Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/386614fab16a4a64b5b36ff799c0bd15
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spelling	oai:doaj.org-article:386614fab16a4a64b5b36ff799c0bd152021-11-25T05:57:52ZControl of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.1932-620310.1371/journal.pone.0109171https://doaj.org/article/386614fab16a4a64b5b36ff799c0bd152014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109171https://doaj.org/toc/1932-6203Although astrocytes are the most abundant cell type in the central nervous system (CNS), little is known about their molecular specification and differentiation. It has previously been reported that transcription factor Nkx6.1 is expressed in neuroepithelial cells that give rise to astrocyte precursors in the ventral spinal cord. In the present study, we systematically investigated the function of Nkx6.1 in astrocyte development using both conventional and conditional Nkx6.1 mutant mice. At early postnatal stages, Nkx6.1 was expressed in a subpopulation of astrocytes in the ventral spinal cord. In the conventional Nkx6.1KO spinal cord, the initial specification of astrocyte progenitors was affected by the mutation, and subsequent migration and differentiation were disrupted in newborn mice. In addition, the development of VA2 subtype astrocytes was also inhibited in the white matter. Further studies with Nkx6.1 conditional mutants revealed significantly delayed differentiation and disorganized arrangement of fibrous astrocytes in the ventral white matter. Together, our studies indicate that Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord.Xiaofeng ZhaoYidan ChenQiang ZhuHao HuangPeng TengKang ZhengXuemei HuBinghua XieZunyi ZhangMaike SanderMengsheng QiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109171 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaofeng Zhao Yidan Chen Qiang Zhu Hao Huang Peng Teng Kang Zheng Xuemei Hu Binghua Xie Zunyi Zhang Maike Sander Mengsheng Qiu Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
description	Although astrocytes are the most abundant cell type in the central nervous system (CNS), little is known about their molecular specification and differentiation. It has previously been reported that transcription factor Nkx6.1 is expressed in neuroepithelial cells that give rise to astrocyte precursors in the ventral spinal cord. In the present study, we systematically investigated the function of Nkx6.1 in astrocyte development using both conventional and conditional Nkx6.1 mutant mice. At early postnatal stages, Nkx6.1 was expressed in a subpopulation of astrocytes in the ventral spinal cord. In the conventional Nkx6.1KO spinal cord, the initial specification of astrocyte progenitors was affected by the mutation, and subsequent migration and differentiation were disrupted in newborn mice. In addition, the development of VA2 subtype astrocytes was also inhibited in the white matter. Further studies with Nkx6.1 conditional mutants revealed significantly delayed differentiation and disorganized arrangement of fibrous astrocytes in the ventral white matter. Together, our studies indicate that Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord.
format	article
author	Xiaofeng Zhao Yidan Chen Qiang Zhu Hao Huang Peng Teng Kang Zheng Xuemei Hu Binghua Xie Zunyi Zhang Maike Sander Mengsheng Qiu
author_facet	Xiaofeng Zhao Yidan Chen Qiang Zhu Hao Huang Peng Teng Kang Zheng Xuemei Hu Binghua Xie Zunyi Zhang Maike Sander Mengsheng Qiu
author_sort	Xiaofeng Zhao
title	Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
title_short	Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
title_full	Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
title_fullStr	Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
title_full_unstemmed	Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
title_sort	control of astrocyte progenitor specification, migration and maturation by nkx6.1 homeodomain transcription factor.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/386614fab16a4a64b5b36ff799c0bd15
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Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.

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