Associating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair

Abstract In their line of duty, Emergency Medical Services (EMS) personnel are exposed to chronically stressful working conditions and recurrent traumatic events, which increase their risk for detrimental health outcomes. Here, we investigated whether this risk is due to altered regulation of the hy...

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Autores principales:	Alexander Behnke, Alexander Karabatsiakis, Aniko Krumbholz, Sarah Karrasch, Gustav Schelling, Iris-Tatjana Kolassa, Roberto Rojas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3867d9e670484d0b8f6dbfa234b11294
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spelling	oai:doaj.org-article:3867d9e670484d0b8f6dbfa234b112942021-12-02T13:46:46ZAssociating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair10.1038/s41598-020-79859-x2045-2322https://doaj.org/article/3867d9e670484d0b8f6dbfa234b112942020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79859-xhttps://doaj.org/toc/2045-2322Abstract In their line of duty, Emergency Medical Services (EMS) personnel are exposed to chronically stressful working conditions and recurrent traumatic events, which increase their risk for detrimental health outcomes. Here, we investigated whether this risk is due to altered regulation of the hypothalamus–pituitary–adrenal (HPA) axis and the endocannabinoid system. Therefore, 1 cm hair strands were collected from a cohort of 72 German EMS personnel in order to measure concentrations of cortisol, endocannabinoids [i.e., anandamide (AEA), 2-arachidonoylglycerol (2-AG)], and N-acylethanolamines [i.e., stearoylethanolamide (SEA), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA)]. Rank correlation analyses were conducted to test associations of cortisol, endocannabinoid, and N-acylethanolamine concentrations with the EMS personnel’s workload, lifetime trauma exposure, and mental and physical health problems. We found a negative correlation between cortisol and 2-AG concentrations in hair. Higher hair cortisol was associated with higher workload. Reported traumatic stress during childhood and later in life as well as more severe depressive and physical stress symptoms were associated with elevated 2-AG, SEA, OEA, and PEA concentrations. Future longitudinal research needs to address the prospect of tracing biomolecular markers of glucocorticoid, endocannabinoid, and N-acylethanolamine activity as a predicting value of the long-term course of mental and physical well-being.Alexander BehnkeAlexander KarabatsiakisAniko KrumbholzSarah KarraschGustav SchellingIris-Tatjana KolassaRoberto RojasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Behnke Alexander Karabatsiakis Aniko Krumbholz Sarah Karrasch Gustav Schelling Iris-Tatjana Kolassa Roberto Rojas Associating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair
description	Abstract In their line of duty, Emergency Medical Services (EMS) personnel are exposed to chronically stressful working conditions and recurrent traumatic events, which increase their risk for detrimental health outcomes. Here, we investigated whether this risk is due to altered regulation of the hypothalamus–pituitary–adrenal (HPA) axis and the endocannabinoid system. Therefore, 1 cm hair strands were collected from a cohort of 72 German EMS personnel in order to measure concentrations of cortisol, endocannabinoids [i.e., anandamide (AEA), 2-arachidonoylglycerol (2-AG)], and N-acylethanolamines [i.e., stearoylethanolamide (SEA), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA)]. Rank correlation analyses were conducted to test associations of cortisol, endocannabinoid, and N-acylethanolamine concentrations with the EMS personnel’s workload, lifetime trauma exposure, and mental and physical health problems. We found a negative correlation between cortisol and 2-AG concentrations in hair. Higher hair cortisol was associated with higher workload. Reported traumatic stress during childhood and later in life as well as more severe depressive and physical stress symptoms were associated with elevated 2-AG, SEA, OEA, and PEA concentrations. Future longitudinal research needs to address the prospect of tracing biomolecular markers of glucocorticoid, endocannabinoid, and N-acylethanolamine activity as a predicting value of the long-term course of mental and physical well-being.
format	article
author	Alexander Behnke Alexander Karabatsiakis Aniko Krumbholz Sarah Karrasch Gustav Schelling Iris-Tatjana Kolassa Roberto Rojas
author_facet	Alexander Behnke Alexander Karabatsiakis Aniko Krumbholz Sarah Karrasch Gustav Schelling Iris-Tatjana Kolassa Roberto Rojas
author_sort	Alexander Behnke
title	Associating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair
title_short	Associating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair
title_full	Associating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair
title_fullStr	Associating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair
title_full_unstemmed	Associating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair
title_sort	associating emergency medical services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and n-acylethanolamine concentrations in their hair
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3867d9e670484d0b8f6dbfa234b11294
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Associating Emergency Medical Services personnel’s workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair

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