NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can be ameliorated with the new drug, NitroSynapsin.

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Autores principales:	Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7
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spelling	oai:doaj.org-article:386d48d4311a447bb8bff05a85d294e72021-12-02T15:38:39ZNitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism10.1038/s41467-017-01563-82041-1723https://doaj.org/article/386d48d4311a447bb8bff05a85d294e72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01563-8https://doaj.org/toc/2041-1723Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can be ameliorated with the new drug, NitroSynapsin.Shichun TuMohd Waseem AkhtarRosa Maria EscorihuelaAlejandro Amador-ArjonaVivek SwarupJames ParkerJeffrey D. ZarembaTimothy HollandNeha BansalDaniel R. HolohanKevin LopezScott D. RyanShing Fai ChanLi YanXiaofei ZhangXiayu HuangAbdullah SultanScott R. McKercherRajesh AmbasudhanHuaxi XuYuqiang WangDaniel H. GeschwindAmanda J. RobertsAlexey V. TerskikhRobert A. RissmanEliezer MasliahStuart A. LiptonNobuki NakanishiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shichun Tu Mohd Waseem Akhtar Rosa Maria Escorihuela Alejandro Amador-Arjona Vivek Swarup James Parker Jeffrey D. Zaremba Timothy Holland Neha Bansal Daniel R. Holohan Kevin Lopez Scott D. Ryan Shing Fai Chan Li Yan Xiaofei Zhang Xiayu Huang Abdullah Sultan Scott R. McKercher Rajesh Ambasudhan Huaxi Xu Yuqiang Wang Daniel H. Geschwind Amanda J. Roberts Alexey V. Terskikh Robert A. Rissman Eliezer Masliah Stuart A. Lipton Nobuki Nakanishi NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
description	Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can be ameliorated with the new drug, NitroSynapsin.
format	article
author	Shichun Tu Mohd Waseem Akhtar Rosa Maria Escorihuela Alejandro Amador-Arjona Vivek Swarup James Parker Jeffrey D. Zaremba Timothy Holland Neha Bansal Daniel R. Holohan Kevin Lopez Scott D. Ryan Shing Fai Chan Li Yan Xiaofei Zhang Xiayu Huang Abdullah Sultan Scott R. McKercher Rajesh Ambasudhan Huaxi Xu Yuqiang Wang Daniel H. Geschwind Amanda J. Roberts Alexey V. Terskikh Robert A. Rissman Eliezer Masliah Stuart A. Lipton Nobuki Nakanishi
author_facet	Shichun Tu Mohd Waseem Akhtar Rosa Maria Escorihuela Alejandro Amador-Arjona Vivek Swarup James Parker Jeffrey D. Zaremba Timothy Holland Neha Bansal Daniel R. Holohan Kevin Lopez Scott D. Ryan Shing Fai Chan Li Yan Xiaofei Zhang Xiayu Huang Abdullah Sultan Scott R. McKercher Rajesh Ambasudhan Huaxi Xu Yuqiang Wang Daniel H. Geschwind Amanda J. Roberts Alexey V. Terskikh Robert A. Rissman Eliezer Masliah Stuart A. Lipton Nobuki Nakanishi
author_sort	Shichun Tu
title	NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
title_short	NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
title_full	NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
title_fullStr	NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
title_full_unstemmed	NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
title_sort	nitrosynapsin therapy for a mouse mef2c haploinsufficiency model of human autism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7
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NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

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