The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study
Abstract Trigeminal input exerts acute and chronic effects on the brain, modulating cognitive functions. Here, new data from humans and animals suggest that these effects are caused by trigeminal influences on the Locus Coeruleus (LC). In humans subjects clenching with masseter asymmetric activity,...
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Nature Portfolio
2021
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oai:doaj.org-article:386dd566ec784dffa286806fa325d4192021-12-02T15:54:10ZThe path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study10.1038/s41598-021-82265-62045-2322https://doaj.org/article/386dd566ec784dffa286806fa325d4192021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82265-6https://doaj.org/toc/2045-2322Abstract Trigeminal input exerts acute and chronic effects on the brain, modulating cognitive functions. Here, new data from humans and animals suggest that these effects are caused by trigeminal influences on the Locus Coeruleus (LC). In humans subjects clenching with masseter asymmetric activity, occlusal correction improved cognition, alongside with reductions in pupil size and anisocoria, proxies of LC activity and asymmetry, respectively. Notably, reductions in pupil size at rest on the hypertonic side predicted cognitive improvements. In adult rats, a distal unilateral section of the trigeminal mandibular branch reduced, on the contralateral side, the expression of c-Fos (brainstem) and BDNF (brainstem, hippocampus, frontal cortex). This counterintuitive finding can be explained by the following model: teeth contact perception loss on the lesioned side results in an increased occlusal effort, which enhances afferent inputs from muscle spindles and posterior periodontal receptors, spared by the distal lesion. Such effort leads to a reduced engagement of the intact side, with a corresponding reduction in the afferent inputs to the LC and in c-Fos and BDNF gene expression. In conclusion, acute effects of malocclusion on performance seem mediated by the LC, which could also contribute to the chronic trophic dysfunction induced by loss of trigeminal input.Maria Paola Tramonti FantozziGiulia LazzariniVincenzo De CiccoAngela BrigantiSerena ArgentoDavide De CiccoMassimo BarresiEnrico CataldoLuca BruschiniPaola d’AscanioAndrea PironeCarla LenziIacopo VannozziVincenzo MiragliottaUgo FaragunaDiego ManzoniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021) |
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Medicine R Science Q Maria Paola Tramonti Fantozzi Giulia Lazzarini Vincenzo De Cicco Angela Briganti Serena Argento Davide De Cicco Massimo Barresi Enrico Cataldo Luca Bruschini Paola d’Ascanio Andrea Pirone Carla Lenzi Iacopo Vannozzi Vincenzo Miragliotta Ugo Faraguna Diego Manzoni The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study |
| description |
Abstract Trigeminal input exerts acute and chronic effects on the brain, modulating cognitive functions. Here, new data from humans and animals suggest that these effects are caused by trigeminal influences on the Locus Coeruleus (LC). In humans subjects clenching with masseter asymmetric activity, occlusal correction improved cognition, alongside with reductions in pupil size and anisocoria, proxies of LC activity and asymmetry, respectively. Notably, reductions in pupil size at rest on the hypertonic side predicted cognitive improvements. In adult rats, a distal unilateral section of the trigeminal mandibular branch reduced, on the contralateral side, the expression of c-Fos (brainstem) and BDNF (brainstem, hippocampus, frontal cortex). This counterintuitive finding can be explained by the following model: teeth contact perception loss on the lesioned side results in an increased occlusal effort, which enhances afferent inputs from muscle spindles and posterior periodontal receptors, spared by the distal lesion. Such effort leads to a reduced engagement of the intact side, with a corresponding reduction in the afferent inputs to the LC and in c-Fos and BDNF gene expression. In conclusion, acute effects of malocclusion on performance seem mediated by the LC, which could also contribute to the chronic trophic dysfunction induced by loss of trigeminal input. |
| format |
article |
| author |
Maria Paola Tramonti Fantozzi Giulia Lazzarini Vincenzo De Cicco Angela Briganti Serena Argento Davide De Cicco Massimo Barresi Enrico Cataldo Luca Bruschini Paola d’Ascanio Andrea Pirone Carla Lenzi Iacopo Vannozzi Vincenzo Miragliotta Ugo Faraguna Diego Manzoni |
| author_facet |
Maria Paola Tramonti Fantozzi Giulia Lazzarini Vincenzo De Cicco Angela Briganti Serena Argento Davide De Cicco Massimo Barresi Enrico Cataldo Luca Bruschini Paola d’Ascanio Andrea Pirone Carla Lenzi Iacopo Vannozzi Vincenzo Miragliotta Ugo Faraguna Diego Manzoni |
| author_sort |
Maria Paola Tramonti Fantozzi |
| title |
The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study |
| title_short |
The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study |
| title_full |
The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study |
| title_fullStr |
The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study |
| title_full_unstemmed |
The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study |
| title_sort |
path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/386dd566ec784dffa286806fa325d419 |
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