SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS

Immunization with xenogeneous tissue antigens is able to interrupt innate immune tolerance interfering immune response to autological analogues. The main part of the differentiation antigens is known to be normally expressed on the surface of numerous organs cells including testis. Thus, anticancer...

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Autores principales:	I. V. Savkin, E. A. Kaschenko, G. V. Seledtsova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	tumor vaccine memory cell neutrophil Science Q
Acceso en línea:	https://doaj.org/article/386f1470ffec4b49ace675ce5b9f9104
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spelling	oai:doaj.org-article:386f1470ffec4b49ace675ce5b9f91042021-11-23T06:14:20ZSPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS2541-94202587-9596https://doaj.org/article/386f1470ffec4b49ace675ce5b9f91042012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/940https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Immunization with xenogeneous tissue antigens is able to interrupt innate immune tolerance interfering immune response to autological analogues. The main part of the differentiation antigens is known to be normally expressed on the surface of numerous organs cells including testis. Thus, anticancer vaccine based on sheep testis spermatogenic epithelium lysed cells reveals notable protective effect in experiment. In this work we decided to investigate immunological aspects of the vaccination resulting in tumor mice lifetime increase. Following, testicular antigen vaccination of the tumor mice is established in addition to the lifetime increase to cause substantial helper and regulatory cells subpopulation increase to stimulate neutrophil release and to intensify tumor neutrophil infiltrate.I. V. SavkinE. A. KaschenkoG. V. SeledtsovaScientific Сentre for Family Health and Human Reproduction Problemsarticletumorvaccinememory cellneutrophilScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 305-308 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	tumor vaccine memory cell neutrophil Science Q
spellingShingle	tumor vaccine memory cell neutrophil Science Q I. V. Savkin E. A. Kaschenko G. V. Seledtsova SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS
description	Immunization with xenogeneous tissue antigens is able to interrupt innate immune tolerance interfering immune response to autological analogues. The main part of the differentiation antigens is known to be normally expressed on the surface of numerous organs cells including testis. Thus, anticancer vaccine based on sheep testis spermatogenic epithelium lysed cells reveals notable protective effect in experiment. In this work we decided to investigate immunological aspects of the vaccination resulting in tumor mice lifetime increase. Following, testicular antigen vaccination of the tumor mice is established in addition to the lifetime increase to cause substantial helper and regulatory cells subpopulation increase to stimulate neutrophil release and to intensify tumor neutrophil infiltrate.
format	article
author	I. V. Savkin E. A. Kaschenko G. V. Seledtsova
author_facet	I. V. Savkin E. A. Kaschenko G. V. Seledtsova
author_sort	I. V. Savkin
title	SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS
title_short	SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS
title_full	SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS
title_fullStr	SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS
title_full_unstemmed	SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS
title_sort	specific and nonspecific immunoreactivity at the experimental tumor process
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/386f1470ffec4b49ace675ce5b9f9104
work_keys_str_mv	AT ivsavkin specificandnonspecificimmunoreactivityattheexperimentaltumorprocess AT eakaschenko specificandnonspecificimmunoreactivityattheexperimentaltumorprocess AT gvseledtsova specificandnonspecificimmunoreactivityattheexperimentaltumorprocess
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SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS

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