IMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS

Abstract. Seventy-nine children participated in the study including 33 children living in region with developed cement industry (12 with glomerulonephritis, and 21 with obstructive pyelonephritis). A group of comparison consisted of 46 children living in Moscow, including 17 subjects with glomerulon...

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Autores principales:	M. V. Kudin, A. V. Skripkin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines environmental pathogens glomerulonephritis obstructive pyelonephritis nephropathy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/386f3f33806d46918c4f891ccc133b34
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spelling	oai:doaj.org-article:386f3f33806d46918c4f891ccc133b342021-11-18T08:03:40ZIMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS1563-06252313-741X10.15789/1563-0625-2009-6-587-592https://doaj.org/article/386f3f33806d46918c4f891ccc133b342014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/376https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Seventy-nine children participated in the study including 33 children living in region with developed cement industry (12 with glomerulonephritis, and 21 with obstructive pyelonephritis). A group of comparison consisted of 46 children living in Moscow, including 17 subjects with glomerulonephritis and 29 children with obstructive pyelonephritis, and control group of 26 healthy children. ELISA method was used to perform immunological studies. The levels of sCD4, IL-2, IL-6, IL-10, sICAM-1, TNFα were evaluated in blood sera. The data obtained show significant increase of TNFα levels and decreased IL-6 levels (p < 0,05) in children with nephropathy living in regions with unfavorable environmental conditions as compared with control group. A seven-fold increase in TNFα levels, along with more than twofold decrease in IL-6 was revealed among children with obstructive pyelonephritis, as compared with control group (p < 0,05). In children with glomerulonephritis and obstructive pyelonephritis, a distinct increase of sCD4 , as well as decreased IL-2 level (p < 0,05) was registered, as compared with control group. Meanwhile, IL-10 contents in this group of patients was 22,4 times less than the in controls (p < 0,05). In the main group, no enhanced sICAM synthesis was found, both in children with glomerulonephritis and pyelonephritis. In children affected by adverse environmental pathogens, we have shown a prevailing immune inflammation due to hyperproduction of TNFα, IL-6, and activation of sCD4 helpers. Adverse environmental effects inhibit cytokine synthesis, thus reducing production of both pro- and anti-inflammatory cytokines.M. V. KudinA. V. SkripkinSPb RAACIarticlecytokinesenvironmental pathogensglomerulonephritisobstructive pyelonephritisnephropathyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 587-592 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines environmental pathogens glomerulonephritis obstructive pyelonephritis nephropathy Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines environmental pathogens glomerulonephritis obstructive pyelonephritis nephropathy Immunologic diseases. Allergy RC581-607 M. V. Kudin A. V. Skripkin IMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS
description	Abstract. Seventy-nine children participated in the study including 33 children living in region with developed cement industry (12 with glomerulonephritis, and 21 with obstructive pyelonephritis). A group of comparison consisted of 46 children living in Moscow, including 17 subjects with glomerulonephritis and 29 children with obstructive pyelonephritis, and control group of 26 healthy children. ELISA method was used to perform immunological studies. The levels of sCD4, IL-2, IL-6, IL-10, sICAM-1, TNFα were evaluated in blood sera. The data obtained show significant increase of TNFα levels and decreased IL-6 levels (p < 0,05) in children with nephropathy living in regions with unfavorable environmental conditions as compared with control group. A seven-fold increase in TNFα levels, along with more than twofold decrease in IL-6 was revealed among children with obstructive pyelonephritis, as compared with control group (p < 0,05). In children with glomerulonephritis and obstructive pyelonephritis, a distinct increase of sCD4 , as well as decreased IL-2 level (p < 0,05) was registered, as compared with control group. Meanwhile, IL-10 contents in this group of patients was 22,4 times less than the in controls (p < 0,05). In the main group, no enhanced sICAM synthesis was found, both in children with glomerulonephritis and pyelonephritis. In children affected by adverse environmental pathogens, we have shown a prevailing immune inflammation due to hyperproduction of TNFα, IL-6, and activation of sCD4 helpers. Adverse environmental effects inhibit cytokine synthesis, thus reducing production of both pro- and anti-inflammatory cytokines.
format	article
author	M. V. Kudin A. V. Skripkin
author_facet	M. V. Kudin A. V. Skripkin
author_sort	M. V. Kudin
title	IMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS
title_short	IMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS
title_full	IMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS
title_fullStr	IMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS
title_full_unstemmed	IMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS
title_sort	immunological study in children with renal diseases living in regions with unfavorable environmental conditions
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/386f3f33806d46918c4f891ccc133b34
work_keys_str_mv	AT mvkudin immunologicalstudyinchildrenwithrenaldiseaseslivinginregionswithunfavorableenvironmentalconditions AT avskripkin immunologicalstudyinchildrenwithrenaldiseaseslivinginregionswithunfavorableenvironmentalconditions
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IMMUNOLOGICAL STUDY IN CHILDREN WITH RENAL DISEASES LIVING IN REGIONS WITH UNFAVORABLE ENVIRONMENTAL CONDITIONS

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