Eukaryotic transcription factors can track and control their target genes using DNA antennas

To carry out their function, transcription factors must efficiently recognize specific DNA sequence targets, a complex problem in the context of eukaryotic chromatin. Here the authors use single-molecule biophysical experiments, statistical mechanical theory and bioinformatics analyses to conclude t...

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Autores principales:	Milagros Castellanos, Nivin Mothi, Victor Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38700698f55c42fb823accdade214c7c
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id	oai:doaj.org-article:38700698f55c42fb823accdade214c7c
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spelling	oai:doaj.org-article:38700698f55c42fb823accdade214c7c2021-12-02T17:31:25ZEukaryotic transcription factors can track and control their target genes using DNA antennas10.1038/s41467-019-14217-82041-1723https://doaj.org/article/38700698f55c42fb823accdade214c7c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14217-8https://doaj.org/toc/2041-1723To carry out their function, transcription factors must efficiently recognize specific DNA sequence targets, a complex problem in the context of eukaryotic chromatin. Here the authors use single-molecule biophysical experiments, statistical mechanical theory and bioinformatics analyses to conclude that interactions with non-target sequences near promoters serve to increase overall affinity and targeting efficiency.Milagros CastellanosNivin MothiVictor MuñozNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Milagros Castellanos Nivin Mothi Victor Muñoz Eukaryotic transcription factors can track and control their target genes using DNA antennas
description	To carry out their function, transcription factors must efficiently recognize specific DNA sequence targets, a complex problem in the context of eukaryotic chromatin. Here the authors use single-molecule biophysical experiments, statistical mechanical theory and bioinformatics analyses to conclude that interactions with non-target sequences near promoters serve to increase overall affinity and targeting efficiency.
format	article
author	Milagros Castellanos Nivin Mothi Victor Muñoz
author_facet	Milagros Castellanos Nivin Mothi Victor Muñoz
author_sort	Milagros Castellanos
title	Eukaryotic transcription factors can track and control their target genes using DNA antennas
title_short	Eukaryotic transcription factors can track and control their target genes using DNA antennas
title_full	Eukaryotic transcription factors can track and control their target genes using DNA antennas
title_fullStr	Eukaryotic transcription factors can track and control their target genes using DNA antennas
title_full_unstemmed	Eukaryotic transcription factors can track and control their target genes using DNA antennas
title_sort	eukaryotic transcription factors can track and control their target genes using dna antennas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/38700698f55c42fb823accdade214c7c
work_keys_str_mv	AT milagroscastellanos eukaryotictranscriptionfactorscantrackandcontroltheirtargetgenesusingdnaantennas AT nivinmothi eukaryotictranscriptionfactorscantrackandcontroltheirtargetgenesusingdnaantennas AT victormunoz eukaryotictranscriptionfactorscantrackandcontroltheirtargetgenesusingdnaantennas
_version_	1718380605710794752

Eukaryotic transcription factors can track and control their target genes using DNA antennas

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