Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms

Several studies have reported that cellular and soluble components of the tumor microenvironment (TME) play a key role in cancer-initiation and progression. Considering the relevance and the complexity of TME in cancer biology, recent research has focused on the investigation of the TME content, in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesca Cersosimo, Marcella Barbarino, Silvia Lonardi, William Vermi, Antonio Giordano, Cristiana Bellan, Emanuele Giurisato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesothelioma tumor microenvironment inflammation macrophages cancer stem cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/38719ed641b44310a0ec8e15dc9c8e67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:38719ed641b44310a0ec8e15dc9c8e67
record_format	dspace
spelling	oai:doaj.org-article:38719ed641b44310a0ec8e15dc9c8e672021-11-25T17:02:21ZMesothelioma Malignancy and the Microenvironment: Molecular Mechanisms10.3390/cancers132256642072-6694https://doaj.org/article/38719ed641b44310a0ec8e15dc9c8e672021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5664https://doaj.org/toc/2072-6694Several studies have reported that cellular and soluble components of the tumor microenvironment (TME) play a key role in cancer-initiation and progression. Considering the relevance and the complexity of TME in cancer biology, recent research has focused on the investigation of the TME content, in terms of players and informational exchange. Understanding the crosstalk between tumor and non-tumor cells is crucial to design more beneficial anti-cancer therapeutic strategies. Malignant pleural mesothelioma (MPM) is a complex and heterogenous tumor mainly caused by asbestos exposure with few treatment options and low life expectancy after standard therapy. MPM leukocyte infiltration is rich in macrophages. Given the failure of macrophages to eliminate asbestos fibers, these immune cells accumulate in pleural cavity leading to the establishment of a unique inflammatory environment and to the malignant transformation of mesothelial cells. In this inflammatory landscape, stromal and immune cells play a driven role to support tumor development and progression via a bidirectional communication with tumor cells. Characterization of the MPM microenvironment (MPM-ME) may be useful to understand the complexity of mesothelioma biology, such as to identify new molecular druggable targets, with the aim to improve the outcome of the disease. In this review, we summarize the known evidence about the MPM-ME network, including its prognostic and therapeutic relevance.Francesca CersosimoMarcella BarbarinoSilvia LonardiWilliam VermiAntonio GiordanoCristiana BellanEmanuele GiurisatoMDPI AGarticlemesotheliomatumor microenvironmentinflammationmacrophagescancer stem cellsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5664, p 5664 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesothelioma tumor microenvironment inflammation macrophages cancer stem cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	mesothelioma tumor microenvironment inflammation macrophages cancer stem cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Francesca Cersosimo Marcella Barbarino Silvia Lonardi William Vermi Antonio Giordano Cristiana Bellan Emanuele Giurisato Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms
description	Several studies have reported that cellular and soluble components of the tumor microenvironment (TME) play a key role in cancer-initiation and progression. Considering the relevance and the complexity of TME in cancer biology, recent research has focused on the investigation of the TME content, in terms of players and informational exchange. Understanding the crosstalk between tumor and non-tumor cells is crucial to design more beneficial anti-cancer therapeutic strategies. Malignant pleural mesothelioma (MPM) is a complex and heterogenous tumor mainly caused by asbestos exposure with few treatment options and low life expectancy after standard therapy. MPM leukocyte infiltration is rich in macrophages. Given the failure of macrophages to eliminate asbestos fibers, these immune cells accumulate in pleural cavity leading to the establishment of a unique inflammatory environment and to the malignant transformation of mesothelial cells. In this inflammatory landscape, stromal and immune cells play a driven role to support tumor development and progression via a bidirectional communication with tumor cells. Characterization of the MPM microenvironment (MPM-ME) may be useful to understand the complexity of mesothelioma biology, such as to identify new molecular druggable targets, with the aim to improve the outcome of the disease. In this review, we summarize the known evidence about the MPM-ME network, including its prognostic and therapeutic relevance.
format	article
author	Francesca Cersosimo Marcella Barbarino Silvia Lonardi William Vermi Antonio Giordano Cristiana Bellan Emanuele Giurisato
author_facet	Francesca Cersosimo Marcella Barbarino Silvia Lonardi William Vermi Antonio Giordano Cristiana Bellan Emanuele Giurisato
author_sort	Francesca Cersosimo
title	Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms
title_short	Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms
title_full	Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms
title_fullStr	Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms
title_full_unstemmed	Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms
title_sort	mesothelioma malignancy and the microenvironment: molecular mechanisms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/38719ed641b44310a0ec8e15dc9c8e67
work_keys_str_mv	AT francescacersosimo mesotheliomamalignancyandthemicroenvironmentmolecularmechanisms AT marcellabarbarino mesotheliomamalignancyandthemicroenvironmentmolecularmechanisms AT silvialonardi mesotheliomamalignancyandthemicroenvironmentmolecularmechanisms AT williamvermi mesotheliomamalignancyandthemicroenvironmentmolecularmechanisms AT antoniogiordano mesotheliomamalignancyandthemicroenvironmentmolecularmechanisms AT cristianabellan mesotheliomamalignancyandthemicroenvironmentmolecularmechanisms AT emanuelegiurisato mesotheliomamalignancyandthemicroenvironmentmolecularmechanisms
_version_	1718412769476214784

Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms

Ejemplares similares