The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents

Abstract Recent studies suggest immune function dysregulation in depression and anxiety disorders. Elevated pro-inflammatory cytokines may be a marker for immune system dysregulation. No study assessed the correlation between the levels of cytokines in children and adolescents with depression/anxiet...

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Autores principales:	Tomer Mevorach, Michal Taler, Shira Dar, Maya Lebow, Irit Schorr Sapir, Ron Rotkopf, Alan Apter, Silvana Fennig, Alon Chen, Abraham Weizman, Maya Amitai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3873701230bb481fafbbf8668c878f59
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spelling	oai:doaj.org-article:3873701230bb481fafbbf8668c878f592021-12-02T18:25:04ZThe relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents10.1038/s41598-021-90971-42045-2322https://doaj.org/article/3873701230bb481fafbbf8668c878f592021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90971-4https://doaj.org/toc/2045-2322Abstract Recent studies suggest immune function dysregulation in depression and anxiety disorders. Elevated pro-inflammatory cytokines may be a marker for immune system dysregulation. No study assessed the correlation between the levels of cytokines in children and adolescents with depression/anxiety disorders and their parents. In this study, 92 children and adolescents (mean age 13.90 ± 2.41 years) with depression and/or anxiety disorders were treated with fluoxetine. Blood samples were collected before initiation of treatment. One hundred and sixty-four of their parents (mean age 50.6 ± 6.2 years) and 25 parents of healthy children (mean age 38.5 ± 6.2 years) also gave blood samples. Plasma levels of three pro-inflammatory cytokine (TNF-α, IL-6, IL-1β) were measured by enzyme linked immunosorbent assays (ELISA) and compared between depressed/anxious children and their parents. We also compared cytokine levels between parents of children with depression/anxiety and control parents. Mothers of depressed children had higher TNF-α levels than mothers of controls. No significant difference was detected in the fathers. A positive correlation was found between the IL-1β levels of the depressed/anxious boys and their mothers. No such correlation was observed in the fathers. Our conclusions are that higher levels of proinflammatory cytokines may indicate immune system activation in mothers in response to the distress associated with having depressed/anxious offspring. The correlation between IL-1β levels in the mothers and their depressed/anxious children may indicate familial vulnerability to depression and anxiety. Our observation highlights the need for a better understanding of sexual dimorphism in inflammatory responses to stress.Tomer MevorachMichal TalerShira DarMaya LebowIrit Schorr SapirRon RotkopfAlan ApterSilvana FennigAlon ChenAbraham WeizmanMaya AmitaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomer Mevorach Michal Taler Shira Dar Maya Lebow Irit Schorr Sapir Ron Rotkopf Alan Apter Silvana Fennig Alon Chen Abraham Weizman Maya Amitai The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents
description	Abstract Recent studies suggest immune function dysregulation in depression and anxiety disorders. Elevated pro-inflammatory cytokines may be a marker for immune system dysregulation. No study assessed the correlation between the levels of cytokines in children and adolescents with depression/anxiety disorders and their parents. In this study, 92 children and adolescents (mean age 13.90 ± 2.41 years) with depression and/or anxiety disorders were treated with fluoxetine. Blood samples were collected before initiation of treatment. One hundred and sixty-four of their parents (mean age 50.6 ± 6.2 years) and 25 parents of healthy children (mean age 38.5 ± 6.2 years) also gave blood samples. Plasma levels of three pro-inflammatory cytokine (TNF-α, IL-6, IL-1β) were measured by enzyme linked immunosorbent assays (ELISA) and compared between depressed/anxious children and their parents. We also compared cytokine levels between parents of children with depression/anxiety and control parents. Mothers of depressed children had higher TNF-α levels than mothers of controls. No significant difference was detected in the fathers. A positive correlation was found between the IL-1β levels of the depressed/anxious boys and their mothers. No such correlation was observed in the fathers. Our conclusions are that higher levels of proinflammatory cytokines may indicate immune system activation in mothers in response to the distress associated with having depressed/anxious offspring. The correlation between IL-1β levels in the mothers and their depressed/anxious children may indicate familial vulnerability to depression and anxiety. Our observation highlights the need for a better understanding of sexual dimorphism in inflammatory responses to stress.
format	article
author	Tomer Mevorach Michal Taler Shira Dar Maya Lebow Irit Schorr Sapir Ron Rotkopf Alan Apter Silvana Fennig Alon Chen Abraham Weizman Maya Amitai
author_facet	Tomer Mevorach Michal Taler Shira Dar Maya Lebow Irit Schorr Sapir Ron Rotkopf Alan Apter Silvana Fennig Alon Chen Abraham Weizman Maya Amitai
author_sort	Tomer Mevorach
title	The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents
title_short	The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents
title_full	The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents
title_fullStr	The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents
title_full_unstemmed	The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents
title_sort	relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3873701230bb481fafbbf8668c878f59
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The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents

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