Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.

To eliminate Lymphatic filariasis (LF) as a public health problem, the World Health Organization (WHO) recommends that any area with infection prevalence greater than or equal to 1% (denoted by presence of microfilaremia or antigenemia) should receive mass drug administration (MDA) of antifilarial d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Naomi Drexler, Charles H Washington, Maribeth Lovegrove, Caroline Grady, Marie Denise Milord, Thomas Streit, Patrick Lammie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/3876f7f3051146468da6aeb337be5499
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3876f7f3051146468da6aeb337be5499
record_format	dspace
spelling	oai:doaj.org-article:3876f7f3051146468da6aeb337be54992021-11-18T09:15:45ZSecondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.1935-27271935-273510.1371/journal.pntd.0001807https://doaj.org/article/3876f7f3051146468da6aeb337be54992012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071849/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735To eliminate Lymphatic filariasis (LF) as a public health problem, the World Health Organization (WHO) recommends that any area with infection prevalence greater than or equal to 1% (denoted by presence of microfilaremia or antigenemia) should receive mass drug administration (MDA) of antifilarial drugs for at least five consecutive rounds. Areas of low-antigen prevalence (< 1%) are thought to pose little risk for continued transmission of LF. Five low-antigen prevalence communes in Haiti, characterized as part of a national survey, were further assessed for transmission in this study. An initial evaluation of schoolchildren was performed in each commune to identify antigen-positive children who served as index cases for subsequent community surveys conducted among households neighboring the index cases. Global positioning system (GPS) coordinates and immunochromatographic tests (ICT) for filarial antigenemia were collected on approximately 1,600 persons of all ages in the five communes. The relationship between antigen-positive cases in the community and distance from index cases was evaluated using multivariate regression techniques and analyses of spatial clustering. Community surveys demonstrated higher antigen prevalence in three of the five communes than was observed in the original mapping survey; autochthonous cases were found in the same three communes. Regression techniques identified a significantly increased likelihood of being antigen-positive when living within 20 meters of index cases when controlling for age, gender, and commune. Spatial clustering of antigen-positive cases was observed in some, but not all communes. Our results suggest that localized transmission was present even in low-prevalence settings and suggest that better surveillance methods may be needed to detect microfoci of LF transmission.Naomi DrexlerCharles H WashingtonMaribeth LovegroveCaroline GradyMarie Denise MilordThomas StreitPatrick LammiePublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 6, Iss 10, p e1807 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Naomi Drexler Charles H Washington Maribeth Lovegrove Caroline Grady Marie Denise Milord Thomas Streit Patrick Lammie Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.
description	To eliminate Lymphatic filariasis (LF) as a public health problem, the World Health Organization (WHO) recommends that any area with infection prevalence greater than or equal to 1% (denoted by presence of microfilaremia or antigenemia) should receive mass drug administration (MDA) of antifilarial drugs for at least five consecutive rounds. Areas of low-antigen prevalence (< 1%) are thought to pose little risk for continued transmission of LF. Five low-antigen prevalence communes in Haiti, characterized as part of a national survey, were further assessed for transmission in this study. An initial evaluation of schoolchildren was performed in each commune to identify antigen-positive children who served as index cases for subsequent community surveys conducted among households neighboring the index cases. Global positioning system (GPS) coordinates and immunochromatographic tests (ICT) for filarial antigenemia were collected on approximately 1,600 persons of all ages in the five communes. The relationship between antigen-positive cases in the community and distance from index cases was evaluated using multivariate regression techniques and analyses of spatial clustering. Community surveys demonstrated higher antigen prevalence in three of the five communes than was observed in the original mapping survey; autochthonous cases were found in the same three communes. Regression techniques identified a significantly increased likelihood of being antigen-positive when living within 20 meters of index cases when controlling for age, gender, and commune. Spatial clustering of antigen-positive cases was observed in some, but not all communes. Our results suggest that localized transmission was present even in low-prevalence settings and suggest that better surveillance methods may be needed to detect microfoci of LF transmission.
format	article
author	Naomi Drexler Charles H Washington Maribeth Lovegrove Caroline Grady Marie Denise Milord Thomas Streit Patrick Lammie
author_facet	Naomi Drexler Charles H Washington Maribeth Lovegrove Caroline Grady Marie Denise Milord Thomas Streit Patrick Lammie
author_sort	Naomi Drexler
title	Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.
title_short	Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.
title_full	Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.
title_fullStr	Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.
title_full_unstemmed	Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.
title_sort	secondary mapping of lymphatic filariasis in haiti-definition of transmission foci in low-prevalence settings.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3876f7f3051146468da6aeb337be5499
work_keys_str_mv	AT naomidrexler secondarymappingoflymphaticfilariasisinhaitidefinitionoftransmissionfociinlowprevalencesettings AT charleshwashington secondarymappingoflymphaticfilariasisinhaitidefinitionoftransmissionfociinlowprevalencesettings AT maribethlovegrove secondarymappingoflymphaticfilariasisinhaitidefinitionoftransmissionfociinlowprevalencesettings AT carolinegrady secondarymappingoflymphaticfilariasisinhaitidefinitionoftransmissionfociinlowprevalencesettings AT mariedenisemilord secondarymappingoflymphaticfilariasisinhaitidefinitionoftransmissionfociinlowprevalencesettings AT thomasstreit secondarymappingoflymphaticfilariasisinhaitidefinitionoftransmissionfociinlowprevalencesettings AT patricklammie secondarymappingoflymphaticfilariasisinhaitidefinitionoftransmissionfociinlowprevalencesettings
_version_	1718420896914341888

Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.

Ejemplares similares