Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection

Williams et al. confirm that human embryonic stem cell-derived cardiomyocytes express the protein machinery critical for SARS-CoV-2 infection and are susceptible to SARS-CoV-2 spike protein pseudotyped virus infection. They further use this platform as a screen to identify inhibitors of SARS-CoV-2 i...

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Autores principales:	Thomas L. Williams, Maria T. Colzani, Robyn G. C. Macrae, Emma L. Robinson, Stuart Bloor, Edward J. D. Greenwood, Jun Ru Zhan, Gregory Strachan, Rhoda E. Kuc, Duuamene Nyimanu, Janet J. Maguire, Paul J. Lehner, Sanjay Sinha, Anthony P. Davenport
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/38772e0bff5a4477befd0ea1c3205005
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spelling	oai:doaj.org-article:38772e0bff5a4477befd0ea1c32050052021-12-02T16:24:51ZHuman embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection10.1038/s42003-021-02453-y2399-3642https://doaj.org/article/38772e0bff5a4477befd0ea1c32050052021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02453-yhttps://doaj.org/toc/2399-3642Williams et al. confirm that human embryonic stem cell-derived cardiomyocytes express the protein machinery critical for SARS-CoV-2 infection and are susceptible to SARS-CoV-2 spike protein pseudotyped virus infection. They further use this platform as a screen to identify inhibitors of SARS-CoV-2 infection, reporting benztropine (targeting B0AT1/ACE2 complex) and DX600 (targeting ACE2) as potential inhibitors.Thomas L. WilliamsMaria T. ColzaniRobyn G. C. MacraeEmma L. RobinsonStuart BloorEdward J. D. GreenwoodJun Ru ZhanGregory StrachanRhoda E. KucDuuamene NyimanuJanet J. MaguirePaul J. LehnerSanjay SinhaAnthony P. DavenportNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Thomas L. Williams Maria T. Colzani Robyn G. C. Macrae Emma L. Robinson Stuart Bloor Edward J. D. Greenwood Jun Ru Zhan Gregory Strachan Rhoda E. Kuc Duuamene Nyimanu Janet J. Maguire Paul J. Lehner Sanjay Sinha Anthony P. Davenport Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
description	Williams et al. confirm that human embryonic stem cell-derived cardiomyocytes express the protein machinery critical for SARS-CoV-2 infection and are susceptible to SARS-CoV-2 spike protein pseudotyped virus infection. They further use this platform as a screen to identify inhibitors of SARS-CoV-2 infection, reporting benztropine (targeting B0AT1/ACE2 complex) and DX600 (targeting ACE2) as potential inhibitors.
format	article
author	Thomas L. Williams Maria T. Colzani Robyn G. C. Macrae Emma L. Robinson Stuart Bloor Edward J. D. Greenwood Jun Ru Zhan Gregory Strachan Rhoda E. Kuc Duuamene Nyimanu Janet J. Maguire Paul J. Lehner Sanjay Sinha Anthony P. Davenport
author_facet	Thomas L. Williams Maria T. Colzani Robyn G. C. Macrae Emma L. Robinson Stuart Bloor Edward J. D. Greenwood Jun Ru Zhan Gregory Strachan Rhoda E. Kuc Duuamene Nyimanu Janet J. Maguire Paul J. Lehner Sanjay Sinha Anthony P. Davenport
author_sort	Thomas L. Williams
title	Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
title_short	Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
title_full	Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
title_fullStr	Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
title_full_unstemmed	Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
title_sort	human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of sars-cov-2 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/38772e0bff5a4477befd0ea1c3205005
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Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection

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