Direct protein-lipid interactions shape the conformational landscape of secondary transporters

Secondary transporters catalyse substrate translocation across the cell membrane but the role of lipids during the transport cycle remains unclear. Here authors used hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations to understand how lipids regulate the conformational...

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Autores principales:	Chloe Martens, Mrinal Shekhar, Antoni J. Borysik, Andy M. Lau, Eamonn Reading, Emad Tajkhorshid, Paula J. Booth, Argyris Politis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3878486fe69c4a06a829c58c6f048e54
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spelling	oai:doaj.org-article:3878486fe69c4a06a829c58c6f048e542021-12-02T14:39:09ZDirect protein-lipid interactions shape the conformational landscape of secondary transporters10.1038/s41467-018-06704-12041-1723https://doaj.org/article/3878486fe69c4a06a829c58c6f048e542018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06704-1https://doaj.org/toc/2041-1723Secondary transporters catalyse substrate translocation across the cell membrane but the role of lipids during the transport cycle remains unclear. Here authors used hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations to understand how lipids regulate the conformational dynamics of secondary transporters.Chloe MartensMrinal ShekharAntoni J. BorysikAndy M. LauEamonn ReadingEmad TajkhorshidPaula J. BoothArgyris PolitisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chloe Martens Mrinal Shekhar Antoni J. Borysik Andy M. Lau Eamonn Reading Emad Tajkhorshid Paula J. Booth Argyris Politis Direct protein-lipid interactions shape the conformational landscape of secondary transporters
description	Secondary transporters catalyse substrate translocation across the cell membrane but the role of lipids during the transport cycle remains unclear. Here authors used hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations to understand how lipids regulate the conformational dynamics of secondary transporters.
format	article
author	Chloe Martens Mrinal Shekhar Antoni J. Borysik Andy M. Lau Eamonn Reading Emad Tajkhorshid Paula J. Booth Argyris Politis
author_facet	Chloe Martens Mrinal Shekhar Antoni J. Borysik Andy M. Lau Eamonn Reading Emad Tajkhorshid Paula J. Booth Argyris Politis
author_sort	Chloe Martens
title	Direct protein-lipid interactions shape the conformational landscape of secondary transporters
title_short	Direct protein-lipid interactions shape the conformational landscape of secondary transporters
title_full	Direct protein-lipid interactions shape the conformational landscape of secondary transporters
title_fullStr	Direct protein-lipid interactions shape the conformational landscape of secondary transporters
title_full_unstemmed	Direct protein-lipid interactions shape the conformational landscape of secondary transporters
title_sort	direct protein-lipid interactions shape the conformational landscape of secondary transporters
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3878486fe69c4a06a829c58c6f048e54
work_keys_str_mv	AT chloemartens directproteinlipidinteractionsshapetheconformationallandscapeofsecondarytransporters AT mrinalshekhar directproteinlipidinteractionsshapetheconformationallandscapeofsecondarytransporters AT antonijborysik directproteinlipidinteractionsshapetheconformationallandscapeofsecondarytransporters AT andymlau directproteinlipidinteractionsshapetheconformationallandscapeofsecondarytransporters AT eamonnreading directproteinlipidinteractionsshapetheconformationallandscapeofsecondarytransporters AT emadtajkhorshid directproteinlipidinteractionsshapetheconformationallandscapeofsecondarytransporters AT paulajbooth directproteinlipidinteractionsshapetheconformationallandscapeofsecondarytransporters AT argyrispolitis directproteinlipidinteractionsshapetheconformationallandscapeofsecondarytransporters
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Direct protein-lipid interactions shape the conformational landscape of secondary transporters

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