Direct protein-lipid interactions shape the conformational landscape of secondary transporters

Secondary transporters catalyse substrate translocation across the cell membrane but the role of lipids during the transport cycle remains unclear. Here authors used hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations to understand how lipids regulate the conformational...

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Bibliographic Details
Main Authors: Chloe Martens, Mrinal Shekhar, Antoni J. Borysik, Andy M. Lau, Eamonn Reading, Emad Tajkhorshid, Paula J. Booth, Argyris Politis
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/3878486fe69c4a06a829c58c6f048e54
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