Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during lesion removal.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yanhao Lai, Helen Budworth, Jill M. Beaver, Nelson L. S. Chan, Zunzhen Zhang, Cynthia T. McMurray, Yuan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3879ba8a8aee40aca671630c5cc0af1e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3879ba8a8aee40aca671630c5cc0af1e
record_format	dspace
spelling	oai:doaj.org-article:3879ba8a8aee40aca671630c5cc0af1e2021-12-02T14:39:15ZCrosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair10.1038/ncomms124652041-1723https://doaj.org/article/3879ba8a8aee40aca671630c5cc0af1e2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12465https://doaj.org/toc/2041-1723The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during lesion removal.Yanhao LaiHelen BudworthJill M. BeaverNelson L. S. ChanZunzhen ZhangCynthia T. McMurrayYuan LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanhao Lai Helen Budworth Jill M. Beaver Nelson L. S. Chan Zunzhen Zhang Cynthia T. McMurray Yuan Liu Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
description	The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during lesion removal.
format	article
author	Yanhao Lai Helen Budworth Jill M. Beaver Nelson L. S. Chan Zunzhen Zhang Cynthia T. McMurray Yuan Liu
author_facet	Yanhao Lai Helen Budworth Jill M. Beaver Nelson L. S. Chan Zunzhen Zhang Cynthia T. McMurray Yuan Liu
author_sort	Yanhao Lai
title	Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_short	Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_full	Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_fullStr	Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_full_unstemmed	Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
title_sort	crosstalk between msh2–msh3 and polβ promotes trinucleotide repeat expansion during base excision repair
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3879ba8a8aee40aca671630c5cc0af1e
work_keys_str_mv	AT yanhaolai crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair AT helenbudworth crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair AT jillmbeaver crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair AT nelsonlschan crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair AT zunzhenzhang crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair AT cynthiatmcmurray crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair AT yuanliu crosstalkbetweenmsh2msh3andpolbpromotestrinucleotiderepeatexpansionduringbaseexcisionrepair
_version_	1718390649210798080

Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

Ejemplares similares