M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

Abstract Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we herein designed M2 macrophage microvesic...

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Autores principales:	Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang, Yaping Li, Zhiwen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cancer stem cells Macrophage Microvesicle Nanoparticles Cabazitaxel Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/387b183d8181482cb25515edc2e58bb8
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spelling	oai:doaj.org-article:387b183d8181482cb25515edc2e58bb82021-11-28T12:26:30ZM2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors10.1186/s12951-021-01143-51477-3155https://doaj.org/article/387b183d8181482cb25515edc2e58bb82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01143-5https://doaj.org/toc/1477-3155Abstract Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we herein designed M2 macrophage microvesicle-inspired nanovehicle of cabazitaxel (M-CFN) to promote accessibility to cancer cells and CSCs in tumors. In the 4T1 tumor model, M-CFN flexibly permeated the tumor mass, accessed cancer cells and CD90-positive cells, and significantly promoted their entry into CSC fractions in tumors. Moreover, M-CFN treatment profoundly eliminated aldehyde dehydrogenase (ALDH)-expressing CSCs in 4T1 and MCF-7 tumors, produced notable depression of tumor growth and caused 93.86% suppression of lung metastasis in 4T1 models. Therefore, the M2 macrophage microvesicle-inspired nanovehicle provides an encouraging strategy to penetrate the tumor tissues and access these insult cells in tumors for effective cancer therapy. Graphical AbstractYuqi WangXiang GongJie LiHong WangXiaoxuan XuYao WuJiaoying WangSiling WangYaping LiZhiwen ZhangBMCarticleCancer stem cellsMacrophageMicrovesicleNanoparticlesCabazitaxelBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer stem cells Macrophage Microvesicle Nanoparticles Cabazitaxel Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Cancer stem cells Macrophage Microvesicle Nanoparticles Cabazitaxel Biotechnology TP248.13-248.65 Medical technology R855-855.5 Yuqi Wang Xiang Gong Jie Li Hong Wang Xiaoxuan Xu Yao Wu Jiaoying Wang Siling Wang Yaping Li Zhiwen Zhang M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
description	Abstract Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we herein designed M2 macrophage microvesicle-inspired nanovehicle of cabazitaxel (M-CFN) to promote accessibility to cancer cells and CSCs in tumors. In the 4T1 tumor model, M-CFN flexibly permeated the tumor mass, accessed cancer cells and CD90-positive cells, and significantly promoted their entry into CSC fractions in tumors. Moreover, M-CFN treatment profoundly eliminated aldehyde dehydrogenase (ALDH)-expressing CSCs in 4T1 and MCF-7 tumors, produced notable depression of tumor growth and caused 93.86% suppression of lung metastasis in 4T1 models. Therefore, the M2 macrophage microvesicle-inspired nanovehicle provides an encouraging strategy to penetrate the tumor tissues and access these insult cells in tumors for effective cancer therapy. Graphical Abstract
format	article
author	Yuqi Wang Xiang Gong Jie Li Hong Wang Xiaoxuan Xu Yao Wu Jiaoying Wang Siling Wang Yaping Li Zhiwen Zhang
author_facet	Yuqi Wang Xiang Gong Jie Li Hong Wang Xiaoxuan Xu Yao Wu Jiaoying Wang Siling Wang Yaping Li Zhiwen Zhang
author_sort	Yuqi Wang
title	M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
title_short	M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
title_full	M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
title_fullStr	M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
title_full_unstemmed	M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
title_sort	m2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
publisher	BMC
publishDate	2021
url	https://doaj.org/article/387b183d8181482cb25515edc2e58bb8
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M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

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