Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin

Abstract. Batubara R, Wirjosentono B, Siregar AH, Harahap U, Tamrin. 2021. Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin. Biodiversitas 22: 2884-2890. Agarwood plants (Aquilaria malaccensi...

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Autores principales:	Ridwanti Batubara, BASUKI WIRJOSENTONO, AMIR HAMZAH SIREGAR, URIP HARAHAP, TAMRIN TAMRIN
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2021
Materias:	agarwood leaves bacteria fungi inhibition zone’s diameter skin Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/387b668d757144dd83ea8a4a8f05f12b
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spelling	oai:doaj.org-article:387b668d757144dd83ea8a4a8f05f12b2021-11-22T12:13:35ZBioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin1412-033X2085-472210.13057/biodiv/d220553https://doaj.org/article/387b668d757144dd83ea8a4a8f05f12b2021-05-01T00:00:00Zhttps://smujo.id/biodiv/article/view/7769https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Batubara R, Wirjosentono B, Siregar AH, Harahap U, Tamrin. 2021. Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin. Biodiversitas 22: 2884-2890. Agarwood plants (Aquilaria malaccensis Lamk.) provide numerous benefits and have been cultivated by the people. The leaves containing various compounds, such as flavonoids, glycosides, triterpenoids and tannins with antibacterial and antifungal activities, were reported to be potential for flesh wound healing. Therefore, research on these activities against microorganisms that cause infection in wounds was carried out in vitro. This research aims to determine the antibacterial and antifungal activities of agarwood leaves ethanol extract against three bacteria species (Staphylococcus epidermidis, Staphylococcus aureus, and Propionibacterium acnes) and two fungi species (Candida albicans and Trichophyton sp.) that commonly cause skin infection. The results of this research show that the concentration of ethanol extract of agarwood leaves affected the bacterial and fungal growth inhibition zone’s diameter. The best inhibitory potential occurred at 5% concentration in activity against bacteria and fungi. The extract’s active compounds contributing to the antimicrobial activity were the flavonoids and tannins. Furthermore, GC-MS identification shows that the ethanol extract from agarwood leaves contained Disulfide, dioctyl; 6,7-Dimethylquinoxaline; (E)-1,3-Di-m-tolylallyl ethyl Carbonate; 5-(2-Methoxyphenyl)-1,2-dihydropyrazol-3-one; 9-[(tert-Butyldimethylsilyl)oxy]benzo[3,4]cyclod ec-3-ene-1,5-diyne; Neophytadiene, 2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, [R-[R,R-(E)]]-; Hexadecanoic acid, methyl ester and a-(3-chloro-4-hydroxyphenyl)-aphenoxy-a-phenyl acetonitrileRidwanti BatubaraBASUKI WIRJOSENTONOAMIR HAMZAH SIREGARURIP HARAHAPTAMRIN TAMRINMBI & UNS Soloarticleagarwood leavesbacteriafungiinhibition zone’s diameterskinBiology (General)QH301-705.5ENBiodiversitas, Vol 22, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	agarwood leaves bacteria fungi inhibition zone’s diameter skin Biology (General) QH301-705.5
spellingShingle	agarwood leaves bacteria fungi inhibition zone’s diameter skin Biology (General) QH301-705.5 Ridwanti Batubara BASUKI WIRJOSENTONO AMIR HAMZAH SIREGAR URIP HARAHAP TAMRIN TAMRIN Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin
description	Abstract. Batubara R, Wirjosentono B, Siregar AH, Harahap U, Tamrin. 2021. Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin. Biodiversitas 22: 2884-2890. Agarwood plants (Aquilaria malaccensis Lamk.) provide numerous benefits and have been cultivated by the people. The leaves containing various compounds, such as flavonoids, glycosides, triterpenoids and tannins with antibacterial and antifungal activities, were reported to be potential for flesh wound healing. Therefore, research on these activities against microorganisms that cause infection in wounds was carried out in vitro. This research aims to determine the antibacterial and antifungal activities of agarwood leaves ethanol extract against three bacteria species (Staphylococcus epidermidis, Staphylococcus aureus, and Propionibacterium acnes) and two fungi species (Candida albicans and Trichophyton sp.) that commonly cause skin infection. The results of this research show that the concentration of ethanol extract of agarwood leaves affected the bacterial and fungal growth inhibition zone’s diameter. The best inhibitory potential occurred at 5% concentration in activity against bacteria and fungi. The extract’s active compounds contributing to the antimicrobial activity were the flavonoids and tannins. Furthermore, GC-MS identification shows that the ethanol extract from agarwood leaves contained Disulfide, dioctyl; 6,7-Dimethylquinoxaline; (E)-1,3-Di-m-tolylallyl ethyl Carbonate; 5-(2-Methoxyphenyl)-1,2-dihydropyrazol-3-one; 9-[(tert-Butyldimethylsilyl)oxy]benzo[3,4]cyclod ec-3-ene-1,5-diyne; Neophytadiene, 2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, [R-[R,R-(E)]]-; Hexadecanoic acid, methyl ester and a-(3-chloro-4-hydroxyphenyl)-aphenoxy-a-phenyl acetonitrile
format	article
author	Ridwanti Batubara BASUKI WIRJOSENTONO AMIR HAMZAH SIREGAR URIP HARAHAP TAMRIN TAMRIN
author_facet	Ridwanti Batubara BASUKI WIRJOSENTONO AMIR HAMZAH SIREGAR URIP HARAHAP TAMRIN TAMRIN
author_sort	Ridwanti Batubara
title	Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin
title_short	Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin
title_full	Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin
title_fullStr	Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin
title_full_unstemmed	Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin
title_sort	bioactive compounds of ethanol extract from agarwood leaves (aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin
publisher	MBI & UNS Solo
publishDate	2021
url	https://doaj.org/article/387b668d757144dd83ea8a4a8f05f12b
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Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin

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