Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy

Abstract Pancreatic cancer is one of the most lethal malignant tumors with a low survival rate, partly because the tumor microenvironment (TME), which consists of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), immune cells, and vascular systems, prevents effective drug delivery an...

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Autores principales:	Ming Jia, Dan Zhang, Chunxiang Zhang, Chunhong Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pancreatic cancer Tumor microenvironment Nano-delivery systems Cancer-associated fibroblasts Extracellular matrix Immunosuppression Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/387c284d8aba4e29b254134fc706ff97
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spelling	oai:doaj.org-article:387c284d8aba4e29b254134fc706ff972021-11-28T12:26:39ZNanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy10.1186/s12951-021-01134-61477-3155https://doaj.org/article/387c284d8aba4e29b254134fc706ff972021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01134-6https://doaj.org/toc/1477-3155Abstract Pancreatic cancer is one of the most lethal malignant tumors with a low survival rate, partly because the tumor microenvironment (TME), which consists of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), immune cells, and vascular systems, prevents effective drug delivery and chemoradiotherapy. Thus, modulating the microenvironment of pancreatic cancer is considered a promising therapeutic approach. Since nanoparticles are one of the most effective cancer treatment strategies, several nano-delivery platforms have been developed to regulate the TME and enhance treatment. Here, we summarize the latest advances in nano-delivery systems that alter the TME in pancreatic cancer by depleting ECM, inhibiting CAFs, reversing immunosuppression, promoting angiogenesis, or improving the hypoxic environment. We also discuss promising new targets for such systems. This review is expected to improve our understanding of how to modulate the pancreatic cancer microenvironment and guide the development of new therapies. Graphical AbstractMing JiaDan ZhangChunxiang ZhangChunhong LiBMCarticlePancreatic cancerTumor microenvironmentNano-delivery systemsCancer-associated fibroblastsExtracellular matrixImmunosuppressionBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pancreatic cancer Tumor microenvironment Nano-delivery systems Cancer-associated fibroblasts Extracellular matrix Immunosuppression Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Pancreatic cancer Tumor microenvironment Nano-delivery systems Cancer-associated fibroblasts Extracellular matrix Immunosuppression Biotechnology TP248.13-248.65 Medical technology R855-855.5 Ming Jia Dan Zhang Chunxiang Zhang Chunhong Li Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy
description	Abstract Pancreatic cancer is one of the most lethal malignant tumors with a low survival rate, partly because the tumor microenvironment (TME), which consists of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), immune cells, and vascular systems, prevents effective drug delivery and chemoradiotherapy. Thus, modulating the microenvironment of pancreatic cancer is considered a promising therapeutic approach. Since nanoparticles are one of the most effective cancer treatment strategies, several nano-delivery platforms have been developed to regulate the TME and enhance treatment. Here, we summarize the latest advances in nano-delivery systems that alter the TME in pancreatic cancer by depleting ECM, inhibiting CAFs, reversing immunosuppression, promoting angiogenesis, or improving the hypoxic environment. We also discuss promising new targets for such systems. This review is expected to improve our understanding of how to modulate the pancreatic cancer microenvironment and guide the development of new therapies. Graphical Abstract
format	article
author	Ming Jia Dan Zhang Chunxiang Zhang Chunhong Li
author_facet	Ming Jia Dan Zhang Chunxiang Zhang Chunhong Li
author_sort	Ming Jia
title	Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy
title_short	Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy
title_full	Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy
title_fullStr	Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy
title_full_unstemmed	Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy
title_sort	nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/387c284d8aba4e29b254134fc706ff97
work_keys_str_mv	AT mingjia nanoparticlebaseddeliverysystemsmodulatethetumormicroenvironmentinpancreaticcancerforenhancedtherapy AT danzhang nanoparticlebaseddeliverysystemsmodulatethetumormicroenvironmentinpancreaticcancerforenhancedtherapy AT chunxiangzhang nanoparticlebaseddeliverysystemsmodulatethetumormicroenvironmentinpancreaticcancerforenhancedtherapy AT chunhongli nanoparticlebaseddeliverysystemsmodulatethetumormicroenvironmentinpancreaticcancerforenhancedtherapy
_version_	1718407944470528000

Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy

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