Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study

Alexei N Kulikov, Sergei V Sosnovskii, Roman D Berezin, Dmitrii S Maltsev, Dzhambulat H Oskanov, Nikolai A Gribanov Department of Ophthalmology, Military Medical Academy, St Petersburg, Russia Purpose: To study vitreoretinal interface (VRI) abnormalities in diabetic macular edema (DME) and the inf...

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Autores principales:	Kulikov AN, Sosnovskii SV, Berezin RD, Maltsev DS, Oskanov DH, Gribanov NA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	diabetic macular edema anti-VEGF optical coherence tomography epiretinal membrane vitreomacular adhesion vitreomacular traction. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/387f2bfaa5824c318e6e012ff8924bb3
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spelling	oai:doaj.org-article:387f2bfaa5824c318e6e012ff8924bb32021-12-02T05:32:06ZVitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study1177-5483https://doaj.org/article/387f2bfaa5824c318e6e012ff8924bb32017-11-01T00:00:00Zhttps://www.dovepress.com/vitreoretinal-interface-abnormalities-in-diabetic-macular-edema-and-ef-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alexei N Kulikov, Sergei V Sosnovskii, Roman D Berezin, Dmitrii S Maltsev, Dzhambulat H Oskanov, Nikolai A Gribanov Department of Ophthalmology, Military Medical Academy, St Petersburg, Russia Purpose: To study vitreoretinal interface (VRI) abnormalities in diabetic macular edema (DME) and the influence of these on the effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) therapy.Methods: VRI status and central retinal thickness (CRT) were evaluated using line and 3D-reference scans obtained using spectral domain-optical coherence tomography RTVue-100 before and 1 month after intravitreal anti-VEGF injection (IVI). VRI status was categorized into five subgroups: normal VRI, retinal surface wrinkling associated with the eccentric epiretinal membrane (ERM), ERM involving the macular center, vitreomacular adhesion (VMA), and vitreomacular traction (VMT).Results: A total of 105 eyes of 89 patients were included in the study. One month after IVI, the mean change of CRT in normal VRI eyes and eyes with VRI abnormalities was –128.0±144.7 µm and –53.0±96.4 µm (p<0.05), respectively. The mean change of CRT 1 month after IVI in each subgroup with VRI abnormalities, apart from the subgroup with retinal wrinkling associated with eccentric ERM, was statistically significantly lower compared to the eyes with normal VRI (p<0.05).Conclusion: VRI abnormalities significantly reduce the effectiveness of intravitreal anti-VEGF therapy in eyes with DME. Eyes with noticeable changes of VRI, including ERM involving the macular center, VMA, and VMT have a poorer response to anti-VEGF therapy compared to eyes with normal VRI or eccentric ERM. Keywords: diabetic macular edema, anti-VEGF, optical coherence tomography, epiretinal membrane, vitreomacular adhesion, vitreomacular tractionKulikov ANSosnovskii SVBerezin RDMaltsev DSOskanov DHGribanov NADove Medical Pressarticlediabetic macular edemaanti-VEGFoptical coherence tomographyepiretinal membranevitreomacular adhesionvitreomacular traction.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1995-2002 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic macular edema anti-VEGF optical coherence tomography epiretinal membrane vitreomacular adhesion vitreomacular traction. Ophthalmology RE1-994
spellingShingle	diabetic macular edema anti-VEGF optical coherence tomography epiretinal membrane vitreomacular adhesion vitreomacular traction. Ophthalmology RE1-994 Kulikov AN Sosnovskii SV Berezin RD Maltsev DS Oskanov DH Gribanov NA Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study
description	Alexei N Kulikov, Sergei V Sosnovskii, Roman D Berezin, Dmitrii S Maltsev, Dzhambulat H Oskanov, Nikolai A Gribanov Department of Ophthalmology, Military Medical Academy, St Petersburg, Russia Purpose: To study vitreoretinal interface (VRI) abnormalities in diabetic macular edema (DME) and the influence of these on the effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) therapy.Methods: VRI status and central retinal thickness (CRT) were evaluated using line and 3D-reference scans obtained using spectral domain-optical coherence tomography RTVue-100 before and 1 month after intravitreal anti-VEGF injection (IVI). VRI status was categorized into five subgroups: normal VRI, retinal surface wrinkling associated with the eccentric epiretinal membrane (ERM), ERM involving the macular center, vitreomacular adhesion (VMA), and vitreomacular traction (VMT).Results: A total of 105 eyes of 89 patients were included in the study. One month after IVI, the mean change of CRT in normal VRI eyes and eyes with VRI abnormalities was –128.0±144.7 µm and –53.0±96.4 µm (p<0.05), respectively. The mean change of CRT 1 month after IVI in each subgroup with VRI abnormalities, apart from the subgroup with retinal wrinkling associated with eccentric ERM, was statistically significantly lower compared to the eyes with normal VRI (p<0.05).Conclusion: VRI abnormalities significantly reduce the effectiveness of intravitreal anti-VEGF therapy in eyes with DME. Eyes with noticeable changes of VRI, including ERM involving the macular center, VMA, and VMT have a poorer response to anti-VEGF therapy compared to eyes with normal VRI or eccentric ERM. Keywords: diabetic macular edema, anti-VEGF, optical coherence tomography, epiretinal membrane, vitreomacular adhesion, vitreomacular traction
format	article
author	Kulikov AN Sosnovskii SV Berezin RD Maltsev DS Oskanov DH Gribanov NA
author_facet	Kulikov AN Sosnovskii SV Berezin RD Maltsev DS Oskanov DH Gribanov NA
author_sort	Kulikov AN
title	Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study
title_short	Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study
title_full	Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study
title_fullStr	Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study
title_full_unstemmed	Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study
title_sort	vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-vegf therapy: an optical coherence tomography study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/387f2bfaa5824c318e6e012ff8924bb3
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Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study

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