Placebo analgesia affects brain correlates of error processing.

Placebo analgesia (PA) is accompanied by decreased activity in pain-related brain regions, but also by greater prefrontal cortex (PFC) activation, which has been suggested to reflect increases in top-down cognitive control and regulation of pain. Here we test whether PA is associated with altered pr...

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Autores principales:	Leonie Koban, Marcel Brass, Margaret T Lynn, Gilles Pourtois
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3881f13bf0454dcf970c1f13a3a51b23
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spelling	oai:doaj.org-article:3881f13bf0454dcf970c1f13a3a51b232021-11-18T08:07:54ZPlacebo analgesia affects brain correlates of error processing.1932-620310.1371/journal.pone.0049784https://doaj.org/article/3881f13bf0454dcf970c1f13a3a51b232012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185436/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Placebo analgesia (PA) is accompanied by decreased activity in pain-related brain regions, but also by greater prefrontal cortex (PFC) activation, which has been suggested to reflect increases in top-down cognitive control and regulation of pain. Here we test whether PA is associated with altered prefrontal monitoring functions that could adjust nociceptive processing to a mismatch between expected and experienced pain. We recorded event-related potentials to response errors in a go/nogo task during placebo vs. a matched control condition. Error commission was associated with two well-described components, the error-related negativity (ERN) and the error positivity (Pe). Results show that the Pe, but not the ERN, was amplified during placebo analgesia compared to the control condition, with neural sources in the lateral and medial PFC. This Pe increase was driven by participants showing a placebo-induced change in pain tolerance, but was absent in the group of non-responders. Our results shed new light on the possible functional mechanisms underlying PA, suggesting a placebo-induced transient change in prefrontal error monitoring and control functions.Leonie KobanMarcel BrassMargaret T LynnGilles PourtoisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49784 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leonie Koban Marcel Brass Margaret T Lynn Gilles Pourtois Placebo analgesia affects brain correlates of error processing.
description	Placebo analgesia (PA) is accompanied by decreased activity in pain-related brain regions, but also by greater prefrontal cortex (PFC) activation, which has been suggested to reflect increases in top-down cognitive control and regulation of pain. Here we test whether PA is associated with altered prefrontal monitoring functions that could adjust nociceptive processing to a mismatch between expected and experienced pain. We recorded event-related potentials to response errors in a go/nogo task during placebo vs. a matched control condition. Error commission was associated with two well-described components, the error-related negativity (ERN) and the error positivity (Pe). Results show that the Pe, but not the ERN, was amplified during placebo analgesia compared to the control condition, with neural sources in the lateral and medial PFC. This Pe increase was driven by participants showing a placebo-induced change in pain tolerance, but was absent in the group of non-responders. Our results shed new light on the possible functional mechanisms underlying PA, suggesting a placebo-induced transient change in prefrontal error monitoring and control functions.
format	article
author	Leonie Koban Marcel Brass Margaret T Lynn Gilles Pourtois
author_facet	Leonie Koban Marcel Brass Margaret T Lynn Gilles Pourtois
author_sort	Leonie Koban
title	Placebo analgesia affects brain correlates of error processing.
title_short	Placebo analgesia affects brain correlates of error processing.
title_full	Placebo analgesia affects brain correlates of error processing.
title_fullStr	Placebo analgesia affects brain correlates of error processing.
title_full_unstemmed	Placebo analgesia affects brain correlates of error processing.
title_sort	placebo analgesia affects brain correlates of error processing.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3881f13bf0454dcf970c1f13a3a51b23
work_keys_str_mv	AT leoniekoban placeboanalgesiaaffectsbraincorrelatesoferrorprocessing AT marcelbrass placeboanalgesiaaffectsbraincorrelatesoferrorprocessing AT margarettlynn placeboanalgesiaaffectsbraincorrelatesoferrorprocessing AT gillespourtois placeboanalgesiaaffectsbraincorrelatesoferrorprocessing
_version_	1718422161299865600

Placebo analgesia affects brain correlates of error processing.

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