The biomechanical properties of an epithelial tissue determine the location of its vasculature

Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion...

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Auteurs principaux: Martin Kragl, Rajib Schubert, Haiko Karsjens, Silke Otter, Barbara Bartosinska, Kay Jeruschke, Jürgen Weiss, Chunguang Chen, David Alsteens, Oliver Kuss, Stephan Speier, Daniel Eberhard, Daniel J. Müller, Eckhard Lammert
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Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/3882207bac40498da5c5335ea5cae3b0
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spelling oai:doaj.org-article:3882207bac40498da5c5335ea5cae3b02021-12-02T16:57:04ZThe biomechanical properties of an epithelial tissue determine the location of its vasculature10.1038/ncomms135602041-1723https://doaj.org/article/3882207bac40498da5c5335ea5cae3b02016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13560https://doaj.org/toc/2041-1723Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion to blood vessels and enabling pancreatic islet vascularization.Martin KraglRajib SchubertHaiko KarsjensSilke OtterBarbara BartosinskaKay JeruschkeJürgen WeissChunguang ChenDavid AlsteensOliver KussStephan SpeierDaniel EberhardDaniel J. MüllerEckhard LammertNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Martin Kragl
Rajib Schubert
Haiko Karsjens
Silke Otter
Barbara Bartosinska
Kay Jeruschke
Jürgen Weiss
Chunguang Chen
David Alsteens
Oliver Kuss
Stephan Speier
Daniel Eberhard
Daniel J. Müller
Eckhard Lammert
The biomechanical properties of an epithelial tissue determine the location of its vasculature
description Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion to blood vessels and enabling pancreatic islet vascularization.
format article
author Martin Kragl
Rajib Schubert
Haiko Karsjens
Silke Otter
Barbara Bartosinska
Kay Jeruschke
Jürgen Weiss
Chunguang Chen
David Alsteens
Oliver Kuss
Stephan Speier
Daniel Eberhard
Daniel J. Müller
Eckhard Lammert
author_facet Martin Kragl
Rajib Schubert
Haiko Karsjens
Silke Otter
Barbara Bartosinska
Kay Jeruschke
Jürgen Weiss
Chunguang Chen
David Alsteens
Oliver Kuss
Stephan Speier
Daniel Eberhard
Daniel J. Müller
Eckhard Lammert
author_sort Martin Kragl
title The biomechanical properties of an epithelial tissue determine the location of its vasculature
title_short The biomechanical properties of an epithelial tissue determine the location of its vasculature
title_full The biomechanical properties of an epithelial tissue determine the location of its vasculature
title_fullStr The biomechanical properties of an epithelial tissue determine the location of its vasculature
title_full_unstemmed The biomechanical properties of an epithelial tissue determine the location of its vasculature
title_sort biomechanical properties of an epithelial tissue determine the location of its vasculature
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3882207bac40498da5c5335ea5cae3b0
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