The biomechanical properties of an epithelial tissue determine the location of its vasculature
Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion...
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oai:doaj.org-article:3882207bac40498da5c5335ea5cae3b02021-12-02T16:57:04ZThe biomechanical properties of an epithelial tissue determine the location of its vasculature10.1038/ncomms135602041-1723https://doaj.org/article/3882207bac40498da5c5335ea5cae3b02016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13560https://doaj.org/toc/2041-1723Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion to blood vessels and enabling pancreatic islet vascularization.Martin KraglRajib SchubertHaiko KarsjensSilke OtterBarbara BartosinskaKay JeruschkeJürgen WeissChunguang ChenDavid AlsteensOliver KussStephan SpeierDaniel EberhardDaniel J. MüllerEckhard LammertNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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Science Q Martin Kragl Rajib Schubert Haiko Karsjens Silke Otter Barbara Bartosinska Kay Jeruschke Jürgen Weiss Chunguang Chen David Alsteens Oliver Kuss Stephan Speier Daniel Eberhard Daniel J. Müller Eckhard Lammert The biomechanical properties of an epithelial tissue determine the location of its vasculature |
description |
Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endocrine pancreatic cells, facilitating their adhesion to blood vessels and enabling pancreatic islet vascularization. |
format |
article |
author |
Martin Kragl Rajib Schubert Haiko Karsjens Silke Otter Barbara Bartosinska Kay Jeruschke Jürgen Weiss Chunguang Chen David Alsteens Oliver Kuss Stephan Speier Daniel Eberhard Daniel J. Müller Eckhard Lammert |
author_facet |
Martin Kragl Rajib Schubert Haiko Karsjens Silke Otter Barbara Bartosinska Kay Jeruschke Jürgen Weiss Chunguang Chen David Alsteens Oliver Kuss Stephan Speier Daniel Eberhard Daniel J. Müller Eckhard Lammert |
author_sort |
Martin Kragl |
title |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
title_short |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
title_full |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
title_fullStr |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
title_full_unstemmed |
The biomechanical properties of an epithelial tissue determine the location of its vasculature |
title_sort |
biomechanical properties of an epithelial tissue determine the location of its vasculature |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/3882207bac40498da5c5335ea5cae3b0 |
work_keys_str_mv |
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