Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells

Autoreactive T cells are removed during their development in the thymus through the functions of medullary thymic epithelial cells (mTEC) and dendritic cells (DC), a process termed negative selection. Here the authors show that mTEC-T cell crosstalk and lymphotoxin α signalling are essential for the...

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Autores principales:	Noëlla Lopes, Jonathan Charaix, Oriane Cédile, Arnauld Sergé, Magali Irla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38851fbf60b04b38b8e9ab0c5008ff5c
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spelling	oai:doaj.org-article:38851fbf60b04b38b8e9ab0c5008ff5c2021-12-02T16:50:11ZLymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells10.1038/s41467-018-03619-92041-1723https://doaj.org/article/38851fbf60b04b38b8e9ab0c5008ff5c2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03619-9https://doaj.org/toc/2041-1723Autoreactive T cells are removed during their development in the thymus through the functions of medullary thymic epithelial cells (mTEC) and dendritic cells (DC), a process termed negative selection. Here the authors show that mTEC-T cell crosstalk and lymphotoxin α signalling are essential for the proper recruitment of DCs into the thymus.Noëlla LopesJonathan CharaixOriane CédileArnauld SergéMagali IrlaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noëlla Lopes Jonathan Charaix Oriane Cédile Arnauld Sergé Magali Irla Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
description	Autoreactive T cells are removed during their development in the thymus through the functions of medullary thymic epithelial cells (mTEC) and dendritic cells (DC), a process termed negative selection. Here the authors show that mTEC-T cell crosstalk and lymphotoxin α signalling are essential for the proper recruitment of DCs into the thymus.
format	article
author	Noëlla Lopes Jonathan Charaix Oriane Cédile Arnauld Sergé Magali Irla
author_facet	Noëlla Lopes Jonathan Charaix Oriane Cédile Arnauld Sergé Magali Irla
author_sort	Noëlla Lopes
title	Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
title_short	Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
title_full	Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
title_fullStr	Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
title_full_unstemmed	Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
title_sort	lymphotoxin α fine-tunes t cell clonal deletion by regulating thymic entry of antigen-presenting cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/38851fbf60b04b38b8e9ab0c5008ff5c
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Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells

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