Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a non-basal/squamous gene expression subtype are most...

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Main Authors:	Ann Taber, Emil Christensen, Philippe Lamy, Iver Nordentoft, Frederik Prip, Sia Viborg Lindskrog, Karin Birkenkamp-Demtröder, Trine Line Hauge Okholm, Michael Knudsen, Jakob Skou Pedersen, Torben Steiniche, Mads Agerbæk, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/3885a19d3a524eca9c7327f222740721
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spelling	oai:doaj.org-article:3885a19d3a524eca9c7327f2227407212021-12-02T18:48:25ZMolecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis10.1038/s41467-020-18640-02041-1723https://doaj.org/article/3885a19d3a524eca9c7327f2227407212020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18640-0https://doaj.org/toc/2041-1723There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a non-basal/squamous gene expression subtype are most likely to respond to treatment.Ann TaberEmil ChristensenPhilippe LamyIver NordentoftFrederik PripSia Viborg LindskrogKarin Birkenkamp-DemtröderTrine Line Hauge OkholmMichael KnudsenJakob Skou PedersenTorben SteinicheMads AgerbækJørgen Bjerggaard JensenLars DyrskjøtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ann Taber Emil Christensen Philippe Lamy Iver Nordentoft Frederik Prip Sia Viborg Lindskrog Karin Birkenkamp-Demtröder Trine Line Hauge Okholm Michael Knudsen Jakob Skou Pedersen Torben Steiniche Mads Agerbæk Jørgen Bjerggaard Jensen Lars Dyrskjøt Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
description	There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a non-basal/squamous gene expression subtype are most likely to respond to treatment.
format	article
author	Ann Taber Emil Christensen Philippe Lamy Iver Nordentoft Frederik Prip Sia Viborg Lindskrog Karin Birkenkamp-Demtröder Trine Line Hauge Okholm Michael Knudsen Jakob Skou Pedersen Torben Steiniche Mads Agerbæk Jørgen Bjerggaard Jensen Lars Dyrskjøt
author_facet	Ann Taber Emil Christensen Philippe Lamy Iver Nordentoft Frederik Prip Sia Viborg Lindskrog Karin Birkenkamp-Demtröder Trine Line Hauge Okholm Michael Knudsen Jakob Skou Pedersen Torben Steiniche Mads Agerbæk Jørgen Bjerggaard Jensen Lars Dyrskjøt
author_sort	Ann Taber
title	Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
title_short	Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
title_full	Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
title_fullStr	Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
title_full_unstemmed	Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
title_sort	molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3885a19d3a524eca9c7327f222740721
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Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

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