Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a non-basal/squamous gene expression subtype are most...
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Nature Portfolio
2020
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oai:doaj.org-article:3885a19d3a524eca9c7327f2227407212021-12-02T18:48:25ZMolecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis10.1038/s41467-020-18640-02041-1723https://doaj.org/article/3885a19d3a524eca9c7327f2227407212020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18640-0https://doaj.org/toc/2041-1723There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a non-basal/squamous gene expression subtype are most likely to respond to treatment.Ann TaberEmil ChristensenPhilippe LamyIver NordentoftFrederik PripSia Viborg LindskrogKarin Birkenkamp-DemtröderTrine Line Hauge OkholmMichael KnudsenJakob Skou PedersenTorben SteinicheMads AgerbækJørgen Bjerggaard JensenLars DyrskjøtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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Science Q Ann Taber Emil Christensen Philippe Lamy Iver Nordentoft Frederik Prip Sia Viborg Lindskrog Karin Birkenkamp-Demtröder Trine Line Hauge Okholm Michael Knudsen Jakob Skou Pedersen Torben Steiniche Mads Agerbæk Jørgen Bjerggaard Jensen Lars Dyrskjøt Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis |
description |
There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a non-basal/squamous gene expression subtype are most likely to respond to treatment. |
format |
article |
author |
Ann Taber Emil Christensen Philippe Lamy Iver Nordentoft Frederik Prip Sia Viborg Lindskrog Karin Birkenkamp-Demtröder Trine Line Hauge Okholm Michael Knudsen Jakob Skou Pedersen Torben Steiniche Mads Agerbæk Jørgen Bjerggaard Jensen Lars Dyrskjøt |
author_facet |
Ann Taber Emil Christensen Philippe Lamy Iver Nordentoft Frederik Prip Sia Viborg Lindskrog Karin Birkenkamp-Demtröder Trine Line Hauge Okholm Michael Knudsen Jakob Skou Pedersen Torben Steiniche Mads Agerbæk Jørgen Bjerggaard Jensen Lars Dyrskjøt |
author_sort |
Ann Taber |
title |
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis |
title_short |
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis |
title_full |
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis |
title_fullStr |
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis |
title_full_unstemmed |
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis |
title_sort |
molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/3885a19d3a524eca9c7327f222740721 |
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