PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B

PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B

Mitochondria in skeletal muscle have distinct localization and properties through unclear mechanisms. Here, the authors use complexome profiling and immunoprecipitations to identify PERM1 as a MICOS-MIB complex interactor that also binds ankyrin B, suggesting PERM1 directs the mitochondria to the me...

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Autores principales: Theresa Bock, Clara Türk, Sriram Aravamudhan, Lena Keufgens, Wilhelm Bloch, Dieu Hien Rozsivalova, Vanina Romanello, Leonardo Nogara, Bert Blaauw, Aleksandra Trifunovic, Thomas Braun, Marcus Krüger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/388735121d3e40b9adaa050527702242
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spelling oai:doaj.org-article:388735121d3e40b9adaa0505277022422021-12-02T16:27:56ZPERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B10.1038/s41467-021-25185-32041-1723https://doaj.org/article/388735121d3e40b9adaa0505277022422021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25185-3https://doaj.org/toc/2041-1723Mitochondria in skeletal muscle have distinct localization and properties through unclear mechanisms. Here, the authors use complexome profiling and immunoprecipitations to identify PERM1 as a MICOS-MIB complex interactor that also binds ankyrin B, suggesting PERM1 directs the mitochondria to the membrane.Theresa BockClara TürkSriram AravamudhanLena KeufgensWilhelm BlochDieu Hien RozsivalovaVanina RomanelloLeonardo NogaraBert BlaauwAleksandra TrifunovicThomas BraunMarcus KrügerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Theresa Bock
Clara Türk
Sriram Aravamudhan
Lena Keufgens
Wilhelm Bloch
Dieu Hien Rozsivalova
Vanina Romanello
Leonardo Nogara
Bert Blaauw
Aleksandra Trifunovic
Thomas Braun
Marcus Krüger
PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B
description Mitochondria in skeletal muscle have distinct localization and properties through unclear mechanisms. Here, the authors use complexome profiling and immunoprecipitations to identify PERM1 as a MICOS-MIB complex interactor that also binds ankyrin B, suggesting PERM1 directs the mitochondria to the membrane.
format article
author Theresa Bock
Clara Türk
Sriram Aravamudhan
Lena Keufgens
Wilhelm Bloch
Dieu Hien Rozsivalova
Vanina Romanello
Leonardo Nogara
Bert Blaauw
Aleksandra Trifunovic
Thomas Braun
Marcus Krüger
author_facet Theresa Bock
Clara Türk
Sriram Aravamudhan
Lena Keufgens
Wilhelm Bloch
Dieu Hien Rozsivalova
Vanina Romanello
Leonardo Nogara
Bert Blaauw
Aleksandra Trifunovic
Thomas Braun
Marcus Krüger
author_sort Theresa Bock
title PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B
title_short PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B
title_full PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B
title_fullStr PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B
title_full_unstemmed PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B
title_sort perm1 interacts with the micos-mib complex to connect the mitochondria and sarcolemma via ankyrin b
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/388735121d3e40b9adaa050527702242
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