Comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43

Abstract The purpose of the study was to compare clinical characteristics and mortality among adults infected with human coronaviruses (HCoV) 229E and OC43. We conducted a retrospective cohort study of adults (≥ 18 years) admitted to the ward of a university teaching hospital for suspected viral inf...

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Autores principales:	Won-Il Choi, In Byung Kim, Sang Joon Park, Eun-Hye Ha, Choong Won Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3887f3f6721b47afa3ee4360ca0c415d
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spelling	oai:doaj.org-article:3887f3f6721b47afa3ee4360ca0c415d2021-12-02T13:19:23ZComparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC4310.1038/s41598-021-83987-32045-2322https://doaj.org/article/3887f3f6721b47afa3ee4360ca0c415d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83987-3https://doaj.org/toc/2045-2322Abstract The purpose of the study was to compare clinical characteristics and mortality among adults infected with human coronaviruses (HCoV) 229E and OC43. We conducted a retrospective cohort study of adults (≥ 18 years) admitted to the ward of a university teaching hospital for suspected viral infection from October 2012 to December 2017. Multiplex real-time polymerase chain reaction (PCR) was used to test for respiratory viruses. Multivariate logistic regression was used to compare mortality among patients with HCoV 229E and HCoV OC43 infections. The main outcome was 30-day all-cause mortality. Of 8071 patients tested, 1689 were found to have a respiratory virus infection. Of these patients, 133 had HCoV infection, including 12 mixed infections, 44 HCoV 229E infections, and 77 HCoV OC43 infections. HCoV 229E infections peaked in January and February, while HCoV OC43 infections occurred throughout the year. The 30-day all-cause mortality was 25.0% among patients with HCoV 229E infection, and 9.1% among patients with HCoV OC43 infection (adjusted odds ratio: 3.58, 95% confidence interval: 1.19–10.75). Infections with HCoVs 229E and OC43 appear to have different seasonal patterns, and HCoV 229E might be more virulent than HCoV OC43.Won-Il ChoiIn Byung KimSang Joon ParkEun-Hye HaChoong Won LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Won-Il Choi In Byung Kim Sang Joon Park Eun-Hye Ha Choong Won Lee Comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43
description	Abstract The purpose of the study was to compare clinical characteristics and mortality among adults infected with human coronaviruses (HCoV) 229E and OC43. We conducted a retrospective cohort study of adults (≥ 18 years) admitted to the ward of a university teaching hospital for suspected viral infection from October 2012 to December 2017. Multiplex real-time polymerase chain reaction (PCR) was used to test for respiratory viruses. Multivariate logistic regression was used to compare mortality among patients with HCoV 229E and HCoV OC43 infections. The main outcome was 30-day all-cause mortality. Of 8071 patients tested, 1689 were found to have a respiratory virus infection. Of these patients, 133 had HCoV infection, including 12 mixed infections, 44 HCoV 229E infections, and 77 HCoV OC43 infections. HCoV 229E infections peaked in January and February, while HCoV OC43 infections occurred throughout the year. The 30-day all-cause mortality was 25.0% among patients with HCoV 229E infection, and 9.1% among patients with HCoV OC43 infection (adjusted odds ratio: 3.58, 95% confidence interval: 1.19–10.75). Infections with HCoVs 229E and OC43 appear to have different seasonal patterns, and HCoV 229E might be more virulent than HCoV OC43.
format	article
author	Won-Il Choi In Byung Kim Sang Joon Park Eun-Hye Ha Choong Won Lee
author_facet	Won-Il Choi In Byung Kim Sang Joon Park Eun-Hye Ha Choong Won Lee
author_sort	Won-Il Choi
title	Comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43
title_short	Comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43
title_full	Comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43
title_fullStr	Comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43
title_full_unstemmed	Comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43
title_sort	comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229e and oc43
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3887f3f6721b47afa3ee4360ca0c415d
work_keys_str_mv	AT wonilchoi comparisonoftheclinicalcharacteristicsandmortalityofadultsinfectedwithhumancoronaviruses229eandoc43 AT inbyungkim comparisonoftheclinicalcharacteristicsandmortalityofadultsinfectedwithhumancoronaviruses229eandoc43 AT sangjoonpark comparisonoftheclinicalcharacteristicsandmortalityofadultsinfectedwithhumancoronaviruses229eandoc43 AT eunhyeha comparisonoftheclinicalcharacteristicsandmortalityofadultsinfectedwithhumancoronaviruses229eandoc43 AT choongwonlee comparisonoftheclinicalcharacteristicsandmortalityofadultsinfectedwithhumancoronaviruses229eandoc43
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Comparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43

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