EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT

BACKGROUND AND OBJECTIVE: Pain is one of the first symptoms of diseases. So many efforts have been applied for pain determination and relief. The aim of this study was to investigate the analgesic effects of chronic consumption of aqueous date fruit extract (ADFE) in male rat.METHODS: This experimen...

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Autores principales:	M Asadi Shekaari, V Sheibani, HA Ebrahimi, M Rismanchian, T Kalantari Pour, MR Afarinesh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	date fruit antinociception tail flick test paw pressure test rat Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/388942f142a54521ac2368e057512981
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spelling	oai:doaj.org-article:388942f142a54521ac2368e0575129812021-11-10T09:07:10ZEFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT1561-41072251-7170https://doaj.org/article/388942f142a54521ac2368e0575129812008-01-01T00:00:00Zhttp://jbums.org/article-1-2487-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Pain is one of the first symptoms of diseases. So many efforts have been applied for pain determination and relief. The aim of this study was to investigate the analgesic effects of chronic consumption of aqueous date fruit extract (ADFE) in male rat.METHODS: This experimental study was performed on 48 male NMRI rats (250±25gr). Animals divided into two groups as follow: control and experimental group. ADFE (10%) was added to drinking water of the experimental group for 21 days. Control group received distilled water. Then formalin, tail flick and paw pressure tests were applied for comparing the two groups.FINDINGS: Aqueous extract of date fruit (10%) in chronic phase of formalin test showed significant difference between two groups in regard to pain decrease (p<0.05), while there was no significant difference between the two groups in acute phase of formalin test and also tail flick and paw pressure tests.CONCLUSION: Since date fruit has shown no effect in acute phase of formalin test, tail flick and paw pressure so it can be concluded that ADFE has no central effects in decreasing pain. Considering the analgesic effect of ADFE on chronic phase of formalin test, it seems that the analgesic effect of ADFE is mainly peripheral and anti-inflammatory.M Asadi Shekaari,V Sheibani,HA Ebrahimi,M RismanchianT Kalantari PourMR AfarineshBabol University of Medical Sciencesarticledate fruitantinociceptiontail flick testpaw pressure testratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 9, Iss 6, Pp 7-12 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	date fruit antinociception tail flick test paw pressure test rat Medicine R Medicine (General) R5-920
spellingShingle	date fruit antinociception tail flick test paw pressure test rat Medicine R Medicine (General) R5-920 M Asadi Shekaari, V Sheibani, HA Ebrahimi, M Rismanchian T Kalantari Pour MR Afarinesh EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT
description	BACKGROUND AND OBJECTIVE: Pain is one of the first symptoms of diseases. So many efforts have been applied for pain determination and relief. The aim of this study was to investigate the analgesic effects of chronic consumption of aqueous date fruit extract (ADFE) in male rat.METHODS: This experimental study was performed on 48 male NMRI rats (250±25gr). Animals divided into two groups as follow: control and experimental group. ADFE (10%) was added to drinking water of the experimental group for 21 days. Control group received distilled water. Then formalin, tail flick and paw pressure tests were applied for comparing the two groups.FINDINGS: Aqueous extract of date fruit (10%) in chronic phase of formalin test showed significant difference between two groups in regard to pain decrease (p<0.05), while there was no significant difference between the two groups in acute phase of formalin test and also tail flick and paw pressure tests.CONCLUSION: Since date fruit has shown no effect in acute phase of formalin test, tail flick and paw pressure so it can be concluded that ADFE has no central effects in decreasing pain. Considering the analgesic effect of ADFE on chronic phase of formalin test, it seems that the analgesic effect of ADFE is mainly peripheral and anti-inflammatory.
format	article
author	M Asadi Shekaari, V Sheibani, HA Ebrahimi, M Rismanchian T Kalantari Pour MR Afarinesh
author_facet	M Asadi Shekaari, V Sheibani, HA Ebrahimi, M Rismanchian T Kalantari Pour MR Afarinesh
author_sort	M Asadi Shekaari,
title	EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT
title_short	EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT
title_full	EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT
title_fullStr	EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT
title_full_unstemmed	EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT
title_sort	effect of long term consumption of aqueous date fruit extract on analgesia response in male rat
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/388942f142a54521ac2368e057512981
work_keys_str_mv	AT masadishekaari effectoflongtermconsumptionofaqueousdatefruitextractonanalgesiaresponseinmalerat AT vsheibani effectoflongtermconsumptionofaqueousdatefruitextractonanalgesiaresponseinmalerat AT haebrahimi effectoflongtermconsumptionofaqueousdatefruitextractonanalgesiaresponseinmalerat AT mrismanchian effectoflongtermconsumptionofaqueousdatefruitextractonanalgesiaresponseinmalerat AT tkalantaripour effectoflongtermconsumptionofaqueousdatefruitextractonanalgesiaresponseinmalerat AT mrafarinesh effectoflongtermconsumptionofaqueousdatefruitextractonanalgesiaresponseinmalerat
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EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT

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