Synaptic proteins in CSF relate to Parkinson’s disease stage markers

Biomarkers: Synaptic proteins give it away The levels of synaptic proteins in the cerebrospinal fluid (CSF) correlate with Parkinson’s disease (PD) severity. Dysfunctional communication between nerve cells is an established hallmark of early stage PD and other neurodegenerative disorders. As synapse...

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Autores principales:	Erika Bereczki, Anna Bogstedt, Kina Höglund, Panagiota Tsitsi, Lovisa Brodin, Clive Ballard, Per Svenningsson, Dag Aarsland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/388e5cf2ffc74b24ba90cf4aac03e2f8
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spelling	oai:doaj.org-article:388e5cf2ffc74b24ba90cf4aac03e2f82021-12-02T16:09:02ZSynaptic proteins in CSF relate to Parkinson’s disease stage markers10.1038/s41531-017-0008-22373-8057https://doaj.org/article/388e5cf2ffc74b24ba90cf4aac03e2f82017-02-01T00:00:00Zhttps://doi.org/10.1038/s41531-017-0008-2https://doaj.org/toc/2373-8057Biomarkers: Synaptic proteins give it away The levels of synaptic proteins in the cerebrospinal fluid (CSF) correlate with Parkinson’s disease (PD) severity. Dysfunctional communication between nerve cells is an established hallmark of early stage PD and other neurodegenerative disorders. As synapses are lost from various brain areas synaptic proteins leak into the CSF, but little is known about how their concentration correlates with disease stage and prognosis. Erika Bereczki and colleagues at the Karolinska Institutet in Sweden measured the concentration of three synaptic proteins in the CSF of 52 patients with PD and 87 controls. They found that the levels of two of them (neurogranin and SNAP25) correlated with the severity of both motor and non-motor symptoms. Further work will determine whether these proteins could aid early detection of PD and help predict disease progression.Erika BereczkiAnna BogstedtKina HöglundPanagiota TsitsiLovisa BrodinClive BallardPer SvenningssonDag AarslandNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 3, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Erika Bereczki Anna Bogstedt Kina Höglund Panagiota Tsitsi Lovisa Brodin Clive Ballard Per Svenningsson Dag Aarsland Synaptic proteins in CSF relate to Parkinson’s disease stage markers
description	Biomarkers: Synaptic proteins give it away The levels of synaptic proteins in the cerebrospinal fluid (CSF) correlate with Parkinson’s disease (PD) severity. Dysfunctional communication between nerve cells is an established hallmark of early stage PD and other neurodegenerative disorders. As synapses are lost from various brain areas synaptic proteins leak into the CSF, but little is known about how their concentration correlates with disease stage and prognosis. Erika Bereczki and colleagues at the Karolinska Institutet in Sweden measured the concentration of three synaptic proteins in the CSF of 52 patients with PD and 87 controls. They found that the levels of two of them (neurogranin and SNAP25) correlated with the severity of both motor and non-motor symptoms. Further work will determine whether these proteins could aid early detection of PD and help predict disease progression.
format	article
author	Erika Bereczki Anna Bogstedt Kina Höglund Panagiota Tsitsi Lovisa Brodin Clive Ballard Per Svenningsson Dag Aarsland
author_facet	Erika Bereczki Anna Bogstedt Kina Höglund Panagiota Tsitsi Lovisa Brodin Clive Ballard Per Svenningsson Dag Aarsland
author_sort	Erika Bereczki
title	Synaptic proteins in CSF relate to Parkinson’s disease stage markers
title_short	Synaptic proteins in CSF relate to Parkinson’s disease stage markers
title_full	Synaptic proteins in CSF relate to Parkinson’s disease stage markers
title_fullStr	Synaptic proteins in CSF relate to Parkinson’s disease stage markers
title_full_unstemmed	Synaptic proteins in CSF relate to Parkinson’s disease stage markers
title_sort	synaptic proteins in csf relate to parkinson’s disease stage markers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/388e5cf2ffc74b24ba90cf4aac03e2f8
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Synaptic proteins in CSF relate to Parkinson’s disease stage markers

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