Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses

Rare side effects of already known chemotherapy drugs are a difficult case for clinician. In this article, there is a description of 15 cases of the development of methemoglobinemia after the use of ifosfamide and cyclophosphamide in the therapy of acute lymphoblastic leukemia and Burkitt lymphoma....

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Autores principales:	Timur T. Valiev, Yulia S. Korkina
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2021
Materias:	methemoglobinemia ifosfamide cyclophosphamide acute lymphoblastic leukemia burkitt’s lymphoma treatment children Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/389244dc321640a0b49dde1164683778
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spelling	oai:doaj.org-article:389244dc321640a0b49dde11646837782021-11-30T17:03:34ZIfosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses1815-14341815-144210.26442/18151434.2020.4.200481https://doaj.org/article/389244dc321640a0b49dde11646837782021-02-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/61199/44283https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Rare side effects of already known chemotherapy drugs are a difficult case for clinician. In this article, there is a description of 15 cases of the development of methemoglobinemia after the use of ifosfamide and cyclophosphamide in the therapy of acute lymphoblastic leukemia and Burkitt lymphoma. And when ifosfamide-induced methemoglobinemia is already described in the world literature as a form of isolated cases, cyclophosphamide-induced one is presented for the first time in this article in our (domestic) clinical practice. Both pathophysiological basis and inducer drugs are described in the article in detail. Special attention is paid to hereditary variants of methemoglobinemia and to possible combinations of hereditary and drug-induced variants. Clinical and laboratory criteria for the methemoglobinemia diagnosis and corresponding treatment recommendations are provided by the authors.Timur T. ValievYulia S. KorkinaIP Habib O.N.articlemethemoglobinemiaifosfamidecyclophosphamideacute lymphoblastic leukemiaburkitt’s lymphomatreatmentchildrenNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 22, Iss 4, Pp 139-142 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	methemoglobinemia ifosfamide cyclophosphamide acute lymphoblastic leukemia burkitt’s lymphoma treatment children Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	methemoglobinemia ifosfamide cyclophosphamide acute lymphoblastic leukemia burkitt’s lymphoma treatment children Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Timur T. Valiev Yulia S. Korkina Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses
description	Rare side effects of already known chemotherapy drugs are a difficult case for clinician. In this article, there is a description of 15 cases of the development of methemoglobinemia after the use of ifosfamide and cyclophosphamide in the therapy of acute lymphoblastic leukemia and Burkitt lymphoma. And when ifosfamide-induced methemoglobinemia is already described in the world literature as a form of isolated cases, cyclophosphamide-induced one is presented for the first time in this article in our (domestic) clinical practice. Both pathophysiological basis and inducer drugs are described in the article in detail. Special attention is paid to hereditary variants of methemoglobinemia and to possible combinations of hereditary and drug-induced variants. Clinical and laboratory criteria for the methemoglobinemia diagnosis and corresponding treatment recommendations are provided by the authors.
format	article
author	Timur T. Valiev Yulia S. Korkina
author_facet	Timur T. Valiev Yulia S. Korkina
author_sort	Timur T. Valiev
title	Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses
title_short	Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses
title_full	Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses
title_fullStr	Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses
title_full_unstemmed	Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses
title_sort	ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses
publisher	IP Habib O.N.
publishDate	2021
url	https://doaj.org/article/389244dc321640a0b49dde1164683778
work_keys_str_mv	AT timurtvaliev ifosfamidecyclofosfamideinducedmethemoglobinemiainpediatricpatientswithhemoblastoses AT yuliaskorkina ifosfamidecyclofosfamideinducedmethemoglobinemiainpediatricpatientswithhemoblastoses
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Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses

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