Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development
Abstract Mice lacking secreted IgM (sIgM −/−) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this effect is unknown. Here, we demonstrate that B cells in sIgM −/− m...
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| Main Authors: | , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
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| Subjects: | |
| Online Access: | https://doaj.org/article/3895420cee06482aa60c257f0ce6ddf6 |
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