Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism

Although some fungal mitochondria lack the calcium uniporter, many intriguingly encode homologs of the uniporter assembly factor MCUR1. Here, the authors show that in budding yeast, the MCUR1 homologs Put6 and Put7 regulate mitochondrial proline metabolism, a function also conserved in human MCUR1.

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Autores principales:	Mohammad Zulkifli, John K. Neff, Shrishiv A. Timbalia, Natalie M. Garza, Yingqi Chen, Jeramie D. Watrous, Marta Murgia, Prachi P. Trivedi, Steven K. Anderson, Dhanendra Tomar, Roland Nilsson, Muniswamy Madesh, Mohit Jain, Vishal M. Gohil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/389bd4b04d3b4af58e574df071abb507
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spelling	oai:doaj.org-article:389bd4b04d3b4af58e574df071abb5072021-12-02T15:14:48ZYeast homologs of human MCUR1 regulate mitochondrial proline metabolism10.1038/s41467-020-18704-12041-1723https://doaj.org/article/389bd4b04d3b4af58e574df071abb5072020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18704-1https://doaj.org/toc/2041-1723Although some fungal mitochondria lack the calcium uniporter, many intriguingly encode homologs of the uniporter assembly factor MCUR1. Here, the authors show that in budding yeast, the MCUR1 homologs Put6 and Put7 regulate mitochondrial proline metabolism, a function also conserved in human MCUR1.Mohammad ZulkifliJohn K. NeffShrishiv A. TimbaliaNatalie M. GarzaYingqi ChenJeramie D. WatrousMarta MurgiaPrachi P. TrivediSteven K. AndersonDhanendra TomarRoland NilssonMuniswamy MadeshMohit JainVishal M. GohilNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohammad Zulkifli John K. Neff Shrishiv A. Timbalia Natalie M. Garza Yingqi Chen Jeramie D. Watrous Marta Murgia Prachi P. Trivedi Steven K. Anderson Dhanendra Tomar Roland Nilsson Muniswamy Madesh Mohit Jain Vishal M. Gohil Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
description	Although some fungal mitochondria lack the calcium uniporter, many intriguingly encode homologs of the uniporter assembly factor MCUR1. Here, the authors show that in budding yeast, the MCUR1 homologs Put6 and Put7 regulate mitochondrial proline metabolism, a function also conserved in human MCUR1.
format	article
author	Mohammad Zulkifli John K. Neff Shrishiv A. Timbalia Natalie M. Garza Yingqi Chen Jeramie D. Watrous Marta Murgia Prachi P. Trivedi Steven K. Anderson Dhanendra Tomar Roland Nilsson Muniswamy Madesh Mohit Jain Vishal M. Gohil
author_facet	Mohammad Zulkifli John K. Neff Shrishiv A. Timbalia Natalie M. Garza Yingqi Chen Jeramie D. Watrous Marta Murgia Prachi P. Trivedi Steven K. Anderson Dhanendra Tomar Roland Nilsson Muniswamy Madesh Mohit Jain Vishal M. Gohil
author_sort	Mohammad Zulkifli
title	Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
title_short	Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
title_full	Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
title_fullStr	Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
title_full_unstemmed	Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
title_sort	yeast homologs of human mcur1 regulate mitochondrial proline metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/389bd4b04d3b4af58e574df071abb507
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Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism

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