An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment

Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. While eighteen rats received a single dose of 20 mg/kg MTX to obtain an injured...

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Autores principales:	Banu Taskin, Mümin Alper Erdoğan, Gürkan Yiğittürk, Sibel Alper, Oytun Erbaş
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/389d3ec6e17b4f0a973c8907a7d6a429
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spelling	oai:doaj.org-article:389d3ec6e17b4f0a973c8907a7d6a4292021-11-22T01:11:19ZAn Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment1687-630X10.1155/2021/6619844https://doaj.org/article/389d3ec6e17b4f0a973c8907a7d6a4292021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6619844https://doaj.org/toc/1687-630XPurpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. While eighteen rats received a single dose of 20 mg/kg MTX to obtain an injured liver model, six rats constituted the control group. Also, the eighteen liver toxicity model created rats were equally divided into two groups, one of which received digoxin 0.1 mg/kg/day digoxin (Group 1) and the other group (Group 2) was given saline (% 0.9NaCl) with a dose of 1 ml/kg/day for ten days. Following the trial, the rats were sacrificed to harvest blood and liver tissue samples to determine blood and tissue MDA, serum ALT, plasma TNF-α, TGF-β, IL-6, IL-1-Beta, and PTX3 levels. Results. MTX’s structural and functional hepatotoxicity was observable and evidenced by relatively worse histopathological scores and increased biochemical marker levels. Digoxin treatment significantly reduced the liver enzyme ALT, plasma TNF-α, TGF-β, PTX3, and MDA levels and decreased histological changes in the liver tissue with MTX-induced hepatotoxicity in the rat model. Conclusion. We suggest that digoxin has an anti-inflammatory and antihepatotoxic effect on the MTX-induced liver injury model.Banu TaskinMümin Alper ErdoğanGürkan YiğittürkSibel AlperOytun ErbaşHindawi LimitedarticleDiseases of the digestive system. GastroenterologyRC799-869ENGastroenterology Research and Practice, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Banu Taskin Mümin Alper Erdoğan Gürkan Yiğittürk Sibel Alper Oytun Erbaş An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
description	Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. While eighteen rats received a single dose of 20 mg/kg MTX to obtain an injured liver model, six rats constituted the control group. Also, the eighteen liver toxicity model created rats were equally divided into two groups, one of which received digoxin 0.1 mg/kg/day digoxin (Group 1) and the other group (Group 2) was given saline (% 0.9NaCl) with a dose of 1 ml/kg/day for ten days. Following the trial, the rats were sacrificed to harvest blood and liver tissue samples to determine blood and tissue MDA, serum ALT, plasma TNF-α, TGF-β, IL-6, IL-1-Beta, and PTX3 levels. Results. MTX’s structural and functional hepatotoxicity was observable and evidenced by relatively worse histopathological scores and increased biochemical marker levels. Digoxin treatment significantly reduced the liver enzyme ALT, plasma TNF-α, TGF-β, PTX3, and MDA levels and decreased histological changes in the liver tissue with MTX-induced hepatotoxicity in the rat model. Conclusion. We suggest that digoxin has an anti-inflammatory and antihepatotoxic effect on the MTX-induced liver injury model.
format	article
author	Banu Taskin Mümin Alper Erdoğan Gürkan Yiğittürk Sibel Alper Oytun Erbaş
author_facet	Banu Taskin Mümin Alper Erdoğan Gürkan Yiğittürk Sibel Alper Oytun Erbaş
author_sort	Banu Taskin
title	An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
title_short	An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
title_full	An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
title_fullStr	An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
title_full_unstemmed	An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
title_sort	experimental study: benefits of digoxin on hepatotoxicity induced by methotrexate treatment
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/389d3ec6e17b4f0a973c8907a7d6a429
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An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment

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